KEGG   DRUG: Metopimazine
Entry
D05010                      Drug                                   
Name
Metopimazine (USAN/INN)
Formula
C22H27N3O3S2
Exact mass
445.1494
Mol weight
445.5981
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
Gastrointestinal agent
 DG01762  Antiemetic
Remark
ATC code: A04AD05
Efficacy
Anti-emetic, Dopamine D2 receptor antagonist
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AD Other antiemetics
     A04AD05 Metopimazine
      D05010  Metopimazine (USAN/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    D05010  Metopimazine
 Gastrointestinal agent
  DG01762  Antiemetic
   D05010  Metopimazine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D05010  Metopimazine (USAN/INN)
Other DBs
CAS: 14008-44-7
PubChem: 47206737
LigandBox: D05010
NIKKAJI: J8.471I
LinkDB
KCF data

ATOM        30
            1   C8y C    29.0698  -20.3857
            2   N1y N    30.2832  -19.6823
            3   C8y C    29.0698  -21.7751
            4   C8x C    27.8565  -19.6823
            5   C8y C    31.4908  -20.3857
            6   S2x S    30.2832  -22.4842
            7   C8x C    27.8565  -22.4842
            8   C8x C    26.6430  -20.3857
            9   C8y C    31.4908  -21.7751
            10  C8x C    32.6983  -19.6823
            11  C8x C    26.6430  -21.7751
            12  C8x C    32.6983  -22.4842
            13  C8y C    33.9058  -20.3857
            14  C8x C    33.9058  -21.7751
            15  S4a S    35.1229  -19.6861
            16  C1b C    30.2842  -17.7604
            17  C1b C    31.5188  -17.0486
            18  C1a C    36.3357  -18.9859
            19  O3c O    35.8233  -20.9022
            20  O3c O    34.4256  -18.4755
            21  C1b C    32.7299  -17.7488
            22  N1y N    33.9511  -17.0443
            23  C1x C    35.1475  -17.7352
            24  C1x C    36.3600  -17.0353
            25  C1y C    36.3601  -15.6353
            26  C1x C    35.1637  -14.9444
            27  C1x C    33.9512  -15.6443
            28  C5a C    37.5604  -14.9420
            29  N1a N    38.7806  -15.6465
            30  O5a O    37.5596  -13.5103
BOND        33
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     5   9 2
            9     5  10 1
            10    7  11 2
            11    9  12 1
            12   10  13 2
            13   12  14 2
            14    6   9 1
            15    8  11 1
            16   13  14 1
            17   13  15 1
            18    2  16 1
            19   16  17 1
            20   15  18 1
            21   15  19 2
            22   15  20 2
            23   17  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   22  27 1
            31   25  28 1
            32   28  29 1
            33   28  30 2

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