KEGG   DRUG: MiglustatHelp
Entry
D05032                      Drug                                   

Name
Miglustat (JAN/USAN/INN);
Brazaves (TN);
Zavesca (TN)
Product
  Generic
Formula
C10H21NO4
Exact mass
219.1471
Mol weight
219.278
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Remark
Therapeutic category: 3999
ATC code: A16AX06
Product: D05032<JP/US>
Efficacy
Lysosomal storage disease treatment, Glucosylceramide synthase inhibitor
  Disease
Type 1 Gaucher disease [DS:H00126]
Target
UGCG [HSA:7357] [KO:K00720]
  Network
N10018  UGCG inhibitor for deficient GBA
  Pathway
hsa00600  Sphingolipid metabolism
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AX Various alimentary tract and metabolism products
     A16AX06 Miglustat
      D05032  Miglustat (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Genetic or Enzyme Disorder: Replacement, Modifiers, Treatment
  Miglustat
   D05032  Miglustat (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D05032  Miglustat (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Hexosyltransferases
    UGCG
     D05032  Miglustat (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D05032
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05032
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05032
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05032
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D05032
BRITE hierarchy
Other DBs
CAS: 72599-27-0
PubChem: 47206759
ChEBI: 50381
ChEMBL: CHEMBL1029
DrugBank: DB00419
PDB-CCD: NBV[PDBj]
LigandBox: D05032
NIKKAJI: J258.518I
LinkDB All DBs
KCF data Show

ATOM        15
            1   C1y C    33.6700  -19.1800
            2   C1y C    33.6700  -20.5800
            3   C1y C    34.8824  -21.2800
            4   C1y C    36.0949  -20.5800
            5   C1x C    36.0949  -19.1800
            6   N1y N    34.8824  -18.4800
            7   O1a O    37.3260  -21.2910
            8   O1a O    32.4576  -21.2800
            9   O1a O    34.8824  -22.6798
            10  C1b C    32.4576  -18.4800
            11  C1b C    34.8824  -17.0802
            12  C1b C    36.0780  -16.3898
            13  C1b C    37.2652  -17.0752
            14  C1a C    38.4566  -16.3872
            15  O1a O    31.2621  -19.1704
BOND        15
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1 #Down
            8     2   8 1 #Down
            9     3   9 1 #Up
            10    1  10 1 #Up
            11    6  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   10  15 1

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