KEGG   DRUG: MinaprineHelp
Entry
D05039                      Drug                                   

Name
Minaprine (USAN/INN);
Cantor (TN)
Formula
C17H22N4O
Exact mass
298.1794
Mol weight
298.3828
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01568  MAO inhibitor
  DG01558  Monoamine oxidase A inhibitor
Enzyme substrate
 DG01644  CYP2D6 substrate
Remark
ATC code: N06AX07
Chemical structure group: DG00954
Efficacy
Antidepressant, Monoamine oxidase A (MAO-A) inhibitor
Target
MAOA [HSA:4128] [KO:K00274]
  Pathway
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX07 Minaprine
      D05039  Minaprine (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Amine oxidases
    MAOA
     D05039  Minaprine (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 25905-77-5
PubChem: 47206766
ChEBI: 51038
ChEMBL: CHEMBL278819
DrugBank: DB00805
LigandBox: D05039
NIKKAJI: J216.777H
LinkDB All DBs
KCF data Show

ATOM        22
            1   C8y C     9.2400  -16.8000
            2   C8x C     9.2400  -18.2000
            3   C8y C    10.4524  -18.9000
            4   C8y C    11.6649  -18.2000
            5   N5x N    11.6649  -16.8000
            6   N5x N    10.4524  -16.1000
            7   C8y C     8.0276  -16.1000
            8   N1b N    12.8960  -18.9110
            9   C1a C    10.4524  -20.2998
            10  C8x C     8.0276  -14.7002
            11  C8x C     6.8151  -14.0002
            12  C8x C     5.6027  -14.7002
            13  C8x C     5.6027  -16.1000
            14  C8x C     6.8151  -16.8000
            15  C1b C    14.1012  -18.2153
            16  C1b C    15.2835  -18.8981
            17  N1y N    16.4775  -18.2088
            18  C1x C    17.6654  -18.8948
            19  C1x C    18.8779  -18.1949
            20  O2x O    18.8780  -16.7949
            21  C1x C    17.6901  -16.1089
            22  C1x C    16.4776  -16.8088
BOND        24
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     4   8 1
            9     3   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    7  14 1
            16    8  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   17  22 1

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