KEGG   DRUG: Nelarabine
Entry
D05134                      Drug                                   
Name
Nelarabine (JAN/USAN/INN);
Nelzarabine (USAN);
Arranon (TN)
Product
ARRANON (Novartis Pharmaceuticals Corporation)
  Generic
NELARABINE (Amneal Pharmaceuticals LLC), NELARABINE (AqVida GmbH), NELARABINE (Dr. Reddy's Laboratories), NELARABINE (Gland Pharma Limited), NELARABINE (Meitheal Pharmaceuticals), NELARABINE (Nexus Pharmaceuticals LLC), NELARABINE (Shorla Oncology), NELARABINE (Zydus Lifesciences Limited), NELARABINE (Zydus Pharmaceuticals USA), NELARABINE (Zydus Pharmaceuticals USA)
Formula
C11H15N5O5
Exact mass
297.1073
Mol weight
297.2673
Structure
Simcomp
Class
Antineoplastic
 DG02018  Antimetabolite
  DG01958  Nucleic acid derivative, antineoplastic
   DG01439  Arabinofuranosyl type antineoplastic
Metabolizing enzyme substrate
 DG02983  ADA substrate
Remark
Therapeutic category: 4229
ATC code: L01BB07
Product: D05134<JP/US>
Efficacy
Antineoplastic, Antimetabolite
  Disease
T-cell acute lymphoblastic leukemia [DS:H00002]
T-cell lymphoblastic lymphoma [DS:H00002]
Target
DNA polymerase
Metabolism
Enzyme: ADA [HSA:100]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01B ANTIMETABOLITES
    L01BB Purine analogues
     L01BB07 Nelarabine
      D05134  Nelarabine (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Antimetabolites
   Nelarabine
    D05134  Nelarabine (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   422  Antimetabolites
    4229  Others
     D05134  Nelarabine (JAN/USAN/INN); Nelzarabine (USAN)
Drug groups [BR:br08330]
 Antineoplastic
  DG02018  Antimetabolite
   DG01958  Nucleic acid derivative, antineoplastic
    DG01439  Arabinofuranosyl type antineoplastic
     D05134  Nelarabine
 Metabolizing enzyme substrate
  DG02983  ADA substrate
   D05134  Nelarabine
Drug classes [BR:br08332]
 Antineoplastic
  DG02018  Antimetabolite
   D05134  Nelarabine
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D05134
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05134
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05134
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05134
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05134
Other DBs
CAS: 121032-29-9
PubChem: 47206859
ChEBI: 63612
LigandBox: D05134
LinkDB
KCF data

ATOM        21
            1   N4y N    32.0322  -15.7888
            2   C8y C    33.0170  -16.6193
            3   C1y C    30.7477  -16.2037
            4   C8x C    32.6448  -14.4430
            5   C8y C    34.3294  -15.8362
            6   N5x N    33.0211  -18.0454
            7   O2x O    29.6092  -15.3511
            8   C1y C    30.3156  -17.4530
            9   N5x N    34.0857  -14.4471
            10  C8y C    35.5269  -16.5024
            11  C8y C    34.2787  -18.7580
            12  C1y C    28.4999  -16.1452
            13  C1y C    28.9320  -17.4530
            14  N5x N    35.5482  -17.9940
            15  O2a O    36.7096  -15.7885
            16  C1b C    27.1805  -15.7190
            17  O1a O    28.4882  -18.7723
            18  O1a O    26.1470  -16.6532
            19  N1a N    34.2969  -20.1733
            20  O1a O    31.1199  -18.5820
            21  C1a C    37.9346  -16.4642
BOND        23
            1     2   6 1
            2     3   7 1
            3     3   8 1
            4     4   9 2
            5     5  10 1
            6     6  11 2
            7     7  12 1
            8     8  13 1
            9    10  14 2
            10   10  15 1
            11   12  16 1 #Up
            12   13  17 1 #Down
            13   16  18 1
            14    5   9 1
            15   11  14 1
            16   12  13 1
            17    1   2 1
            18    3   1 1 #Up
            19    1   4 1
            20    2   5 2
            21   11  19 1
            22    8  20 1 #Up
            23   15  21 1

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