KEGG   DRUG: NepafenacHelp
Entry
D05143                      Drug                                   

Name
Nepafenac (JAN/USAN/INN);
Nevanac (TN)
Product
Formula
C15H14N2O2
Exact mass
254.1055
Mol weight
254.2839
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01906  Antiinflammatory drug, acetic acid derivatives
 DG01504  Nonsteroidal antiinflammatory drug (NSAID)
  DG01906  Antiinflammatory drug, acetic acid derivatives
Remark
Therapeutic category: 1319
ATC code: S01BC10
Product: D05143<JP/US>
Efficacy
Analgesic, Anti-inflammatory, COX inhibitor
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC10 Nepafenac
      D05143  Nepafenac (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Nepafenac
    D05143  Nepafenac (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D05143  Nepafenac (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D05143  Nepafenac (JAN/USAN/INN) <JP/US>
    PTGS2 (COX2)
     D05143  Nepafenac (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D05143
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05143
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05143
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05143
BRITE hierarchy
Other DBs
CAS: 78281-72-8
PubChem: 47206867
ChEBI: 75922
ChEMBL: CHEMBL1021
LigandBox: D05143
NIKKAJI: J332.082K
LinkDB All DBs
KCF data Show

ATOM        19
            1   C8x C     6.3700  -15.1200
            2   C8x C     6.3700  -16.5200
            3   C8x C     7.5824  -17.2200
            4   C8x C     8.7949  -16.5200
            5   C8y C     8.7949  -15.1200
            6   C8x C     7.5824  -14.4200
            7   C8x C    11.2197  -16.5200
            8   C8y C    11.2197  -15.1200
            9   C5a C    10.0073  -14.4200
            10  C8x C    12.4322  -17.2200
            11  C8x C    13.6446  -16.5200
            12  C8y C    13.6446  -15.1200
            13  C8y C    12.4322  -14.4200
            14  O5a O    10.0073  -13.0200
            15  C1b C    14.8611  -14.4177
            16  N1a N    12.4322  -13.0203
            17  C5a C    16.0586  -15.1092
            18  N1a N    17.2449  -14.4243
            19  O5a O    16.0587  -16.5197
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 2
            16   12  15 1
            17   13  16 1
            18   15  17 1
            19   17  18 1
            20   17  19 2

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