KEGG   DRUG: NesiritideHelp
Entry
D05147                      Drug                                   

Name
Nesiritide (USAN/INN);
Natrecor (TN)
Product
Formula
C143H244N50O42S4
Exact mass
3461.7377
Mol weight
3464.0373
Sequence
Ser Pro Lys Met Val Gln Gly Ser Gly Cys Phe Gly Arg Lys Met Asp
Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys Lys Val Leu Arg Arg His
(Disulfide bridge: 10-26)
  Type
Peptide
Remark
ATC code: C01DX19
Chemical structure group: DG00238
Product (DG00238): D05147<US>
Efficacy
Vasodilator, Atrial natriuretic peptide receptor agonist
Comment
Recombinant of human B-type natriuretic peptide (BNP) [HSA:4879]
Renin-angiotensin system antagonist
Treatment of congestive heart failure
Target
NPR1 [HSA:4881] [KO:K12323]
  Pathway
hsa04270  Vascular smooth muscle contraction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01D VASODILATORS USED IN CARDIAC DISEASES
    C01DX Other vasodilators used in cardiac diseases
     C01DX19 Nesiritide
      D05147  Nesiritide (USAN/INN) <US>
Target-based classification of drugs [BR:br08310]
 Enzymes
  Lyases (EC4)
   Phosphorus-oxygen lyases
    NPR1
     D05147  Nesiritide (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D05147
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05147
BRITE hierarchy
Other DBs
CAS: 124584-08-3
PubChem: 47206871
LinkDB All DBs

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