KEGG   DRUG: NivazolHelp
Entry
D05194                      Drug                                   

Name
Nivazol (USAN);
Nivacortol (INN)
Formula
C28H31FN2O
Exact mass
430.242
Mol weight
430.5569
Structure
Mol fileKCF fileDB search
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D05194  Nivazol (USAN)
BRITE hierarchy
Other DBs
CAS: 24358-76-7
PubChem: 47206913
ChEMBL: CHEMBL2106806
LigandBox: D05194
NIKKAJI: J34.236J
LinkDB All DBs
KCF data Show

ATOM        32
            1   C1y C    24.8796  -17.5248
            2   C1y C    26.0499  -18.2153
            3   C1z C    23.7035  -18.1976
            4   C1x C    24.8213  -16.1674
            5   C1y C    27.2317  -17.5365
            6   C1x C    26.0499  -19.5668
            7   C2y C    23.6977  -19.5551
            8   C1x C    22.5333  -17.5248
            9   C1a C    23.6629  -16.8227
            10  C1x C    26.0733  -15.5062
            11  C1z C    27.2494  -16.1908
            12  C1x C    29.6248  -17.5948
            13  C1x C    24.8620  -20.2515
            14  C2x C    22.5333  -20.2456
            15  C8y C    21.3513  -18.1976
            16  C1z C    28.4255  -15.5296
            17  C1a C    27.2497  -14.9094
            18  C1x C    29.5956  -16.2200
            19  C8y C    21.3456  -19.5551
            20  C8x C    20.0641  -17.7764
            21  C3b C    29.6366  -14.6812
            22  O1a O    28.4429  -14.0261
            23  N4y N    20.0584  -19.9705
            24  N5x N    19.2566  -18.8706
            25  C3a C    30.8418  -13.8327
            26  C8y C    19.6350  -21.2740
            27  C8x C    18.2980  -21.5587
            28  C8x C    17.8659  -22.8904
            29  C8y C    18.8031  -23.9304
            30  C8x C    20.1401  -23.6457
            31  C8x C    20.5722  -22.3141
            32  X   F    18.3708  -25.2625
BOND        37
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 2
            14    8  15 1
            15   11  16 1
            16   11  17 1 #Up
            17   12  18 1
            18   14  19 1
            19   15  20 1
            20   16  21 1 #Down
            21   16  22 1
            22   19  23 1
            23   20  24 2
            24   21  25 3
            25    7  13 1
            26   10  11 1
            27   15  19 2
            28   16  18 1
            29   23  24 1
            30   23  26 1
            31   26  27 2
            32   27  28 1
            33   28  29 2
            34   29  30 1
            35   30  31 2
            36   26  31 1
            37   29  32 1

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