KEGG   DRUG: Parathyroid hormone (human)
Entry
D05364                      Drug                                   
Name
Parathyroid hormone (human) (USAN);
Parathyroid hormone (INN);
ALX 1-11;
Parathormone;
PTH;
Natpara (TN)
Product
NATPARA (PARATHYROID HORMONE) (Takeda Pharmaceuticals America)
Formula
C408H674N126O126S2
Exact mass
9418.9648
Mol weight
9424.62
Sequence
H-Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn
Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His
Asn Phe Val Ala Leu Gly Ala Pro Leu Ala Pro Arg Asp Ala Gly Ser
Gln Arg Pro Arg Lys Lys Glu Asp Asn Val Leu Val Glu Ser His Glu
Lys Ser Leu Gly Glu Ala Asp Lys Ala Asp Val Asn Val Leu Thr Lys
Ala Lys Ser Gln-OH
  Type
Peptide
Class
Hormonal agent
 DG01661  Parathyroid hormone and parathyroid hormone-related protein analog
Remark
Same as: C16051
ATC code: H05AA03
Product: D05364<US>
Efficacy
Diagnostic (pseudohypoparathyroidism, hypocalcemia), Osteoporosis agent, Parathyroid hormone receptor agonist
  Disease
Hypoparathyroidism [DS:H01862]
Comment
peptide hormone
Treatment of osteoporosis, as an antiosteoporotic, in the treatment of bone and mineral disease and disorders, bone metabolism regulator, blood calcium regulator
Target
PTH1R [HSA:5745] [KO:K04585]
PTH2R [HSA:5746] [KO:K04586]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04961  Endocrine and other factor-regulated calcium reabsorption
  Network
nt06318  CaSR-PTH signaling
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H05 CALCIUM HOMEOSTASIS
   H05A PARATHYROID HORMONES AND ANALOGUES
    H05AA Parathyroid hormones and analogues
     H05AA03 Parathyroid hormone
      D05364  Parathyroid hormone (human) (USAN) <US>
USP drug classification [BR:br08302]
 Metabolic Bone Disease Agents
  Calcium Regulating Hormones
   Parathyroid Hormone
    D05364  Parathyroid hormone (human) (USAN)
Drug groups [BR:br08330]
 Hormonal agent
  DG01661  Parathyroid hormone and parathyroid hormone-related protein analog
   D05364  Parathyroid hormone (human)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Secretin receptor family
   Parathyroid hormone
    PTH1R
     D05364  Parathyroid hormone (human) (USAN) <US>
    PTH2R
     D05364  Parathyroid hormone (human) (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D05364
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05364
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05364
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D05364
Other DBs
CAS: 68893-82-3
PubChem: 47207043
LinkDB

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