KEGG   DRUG: PiclamilastHelp
Entry
D05474                      Drug                                   

Name
Piclamilast (USAN/INN)
Formula
C18H18Cl2N2O3
Exact mass
380.0694
Mol weight
381.2531
Structure
Mol fileKCF fileDB search
Efficacy
Antiasthmatic, Phosphodiesterase IV inhibitor
Target
PDE4 [HSA:5141 5142 5143 5144] [KO:K13293]
  Pathway
hsa04024  cAMP signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Phosphodiesterase
    PDE4
     D05474  Piclamilast (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 144035-83-6
PubChem: 47207143
ChEBI: 47619
ChEMBL: CHEMBL42126
DrugBank: DB01791
PDB-CCD: PIL[PDBj]
LigandBox: D05474
NIKKAJI: J623.884J
LinkDB All DBs
KCF data Show

ATOM        25
            1   N5x N    32.8300   -8.6800
            2   C8x C    32.8300   -7.2800
            3   C8y C    31.5700   -6.5800
            4   C8y C    30.3800   -7.2800
            5   C8y C    30.3800   -8.6800
            6   C8x C    31.5700   -9.4500
            7   N1b N    29.1200   -6.5800
            8   C5a C    27.9300   -7.2800
            9   X   Cl   31.5700   -5.1800
            10  X   Cl   29.1200   -9.4500
            11  C8y C    26.7400   -6.5800
            12  O5a O    27.9300   -8.6800
            13  C8x C    26.7400   -5.1800
            14  C8x C    25.5500   -4.4800
            15  C8y C    24.2900   -5.1800
            16  C8y C    24.2900   -6.5800
            17  C8x C    25.5500   -7.2800
            18  O2a O    23.1000   -4.4800
            19  O2a O    23.1000   -7.2800
            20  C1y C    23.1000   -8.6800
            21  C1a C    21.9100   -5.1800
            22  C1x C    21.9800   -9.5200
            23  C1x C    22.4000  -10.8500
            24  C1x C    23.8000  -10.8500
            25  C1x C    24.2200   -9.5200
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     3   9 1
            10    5  10 1
            11    8  11 1
            12    8  12 2
            13   11  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   11  17 1
            19   15  18 1
            20   16  19 1
            21   19  20 1
            22   18  21 1
            23   20  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   20  25 1

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