KEGG   DRUG: RimexoloneHelp
Entry
D05729                      Drug                                   

Name
Rimexolone (USP/INN);
Vexol (TN)
Product
Formula
C24H34O3
Exact mass
370.2508
Mol weight
370.525
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
ATC code: H02AB12 S01BA13
Product: D05729<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB12 Rimexolone
      D05729  Rimexolone (USP/INN) <US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA13 Rimexolone
      D05729  Rimexolone (USP/INN) <US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Rimexolone
    D05729  Rimexolone (USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D05729  Rimexolone (USP/INN) <US>
BRITE hierarchy
Other DBs
CAS: 49697-38-3
PubChem: 47207390
ChEMBL: CHEMBL111461 CHEMBL1200617 CHEMBL66608
DrugBank: DB00896
LigandBox: D05729
NIKKAJI: J10.027G
LinkDB All DBs
KCF data Show

ATOM        27
            1   C2x C    22.1941  -19.6507
            2   C5x C    22.1941  -21.0184
            3   C2x C    23.3786  -21.7023
            4   C2y C    24.5631  -21.0184
            5   C1z C    24.5631  -19.6507
            6   C2x C    23.3786  -18.9668
            7   C1x C    25.7477  -21.7023
            8   C1x C    26.9322  -21.0184
            9   C1y C    26.9322  -19.6507
            10  C1y C    25.7477  -18.9668
            11  C1y C    28.1167  -18.9668
            12  C1z C    28.1167  -17.5990
            13  C1x C    26.9322  -16.9151
            14  C1y C    25.7477  -17.5990
            15  C1x C    30.4858  -18.9668
            16  C1y C    30.4858  -17.5990
            17  C1z C    29.3013  -16.9151
            18  C5a C    29.3066  -15.1974
            19  C1a C    28.1211  -16.2312
            20  O1a O    24.5652  -16.9162
            21  C1a C    24.5649  -18.2829
            22  O5x O    21.0096  -21.7023
            23  O5a O    30.4937  -14.5181
            24  C1b C    28.1246  -14.5090
            25  C1a C    26.9292  -15.1928
            26  C1a C    30.5137  -16.2151
            27  C1a C    31.8858  -17.5290
BOND        30
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21   17  18 1 #Up
            22   12  19 1 #Up
            23   14  20 1 #Up
            24    5  21 1 #Up
            25    2  22 2
            26   18  23 2
            27   18  24 1
            28   24  25 1
            29   17  26 1 #Down
            30   16  27 1 #Down

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