| Entry |
|
|---|
| Name |
Tecastemizole (USAN/INN) |
|---|
| Formula |
C19H21FN4
|
|---|
| Exact mass |
324.1750
|
|---|
| Mol weight |
324.39
|
|---|
| Structure |
|
|---|
| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
|
|---|
| Efficacy |
Anti-inflammatory, H1 receptor antagonist |
|---|
| Comment |
Antihistamine used in the treatment of allergic rhinitis
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
|
|---|
| Interaction |
|
|---|
| Brite |
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
D06021 Tecastemizole
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D06021 Tecastemizole (USAN/INN)
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 24
1 C8y C 12.3200 -17.3600
2 C8y C 12.3200 -18.7600
3 N4y N 13.6515 -19.1926
4 C8y C 14.4744 -18.0600
5 N5x N 13.6515 -16.9274
6 C8x C 11.1076 -16.6600
7 C8x C 9.8951 -17.3600
8 C8x C 9.8951 -18.7600
9 C8x C 11.1076 -19.4600
10 N1b N 15.8900 -18.0600
11 C1b C 14.0803 -20.5122
12 C8y C 15.4394 -20.8011
13 C1y C 16.5900 -16.8476
14 C1x C 17.9898 -16.8476
15 C1x C 18.6898 -15.6351
16 N1x N 17.9898 -14.4227
17 C1x C 16.5900 -14.4227
18 C1x C 15.8900 -15.6351
19 C8x C 15.8716 -22.1312
20 C8x C 17.2410 -22.4222
21 C8y C 18.1778 -21.3817
22 C8x C 17.7456 -20.0517
23 C8x C 16.3761 -19.7607
24 X F 19.5615 -21.6762
BOND 27
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 2
5 1 5 1
6 1 6 2
7 6 7 1
8 7 8 2
9 8 9 1
10 2 9 2
11 4 10 1
12 3 11 1
13 11 12 1
14 10 13 1
15 13 14 1
16 14 15 1
17 15 16 1
18 16 17 1
19 17 18 1
20 13 18 1
21 12 19 2
22 19 20 1
23 20 21 2
24 21 22 1
25 22 23 2
26 12 23 1
27 21 24 1
|
|---|
