KEGG   DRUG: Galsulfase
Entry
D06565                      Drug                                   
Name
Galsulfase (USAN/INN);
Galsulfase (genetical recombination) (JAN);
Aryplase (TN)
Product
NAGLAZYME (BioMarin Pharmaceutical)
Formula
C2529H3843N689O716S16
Exact mass
55833.1016
Mol weight
55867.8004
Sequence
AGASRPPHLV FLLADDLGWN DVGFHGSRIR TPHLDALAAG GVLLDNYYTQ PLCTPSRSQL
LTGRYQIRTG LQHQIIWPCQ PSCVPLDEKL LPQLLKEAGY TTHMVGKWHL GMYRKECLPT
RRGFDTYFGY LLGSEDYYSH ERCTLIDALN VTRCALDFRD GEEVATGYKN MYSTNIFTKR
AIALITNHPP EKPLFLYLAL QSVHEPLQVP EEYLKPYDFI QDKNRHHYAG MVSLMDEAVG
NVTAALKSSG LWNNTVFIFS TDNGGQTLAG GNNWPLRGRK WSLWEGGVRG VGFVASPLLK
QKGVKNRELI HISDWLPTLV KLARGHTNGT KPLDGFDVWK TISEGSPSPR IELLHNIDPN
FVDSSPCPRN SMAPAKDDSS LPEYSAFNTS VHAAIRHGNW KLLTGYPGCG YWFPPPSQYN
VSEIPSSDPP TKTLWLFDID RDPEERHDLS REYPHIVTKL LSRLQFYHKH SVPVYFPAQD
PRCDPKATGV WGPWM
  Type
Peptide
Remark
Therapeutic category: 3959
ATC code: A16AB08
Product: D06565<JP/US>
Efficacy
Lysosomal storage disease treatment, Enzyme replacement (arylsulfatase B)
  Disease
Mucopolysaccharidosis VI; Maroteaux-Lamy syndrome [DS:H00131]
  Type
Enzyme replacement therapy product
Target
ARSB* [HSA_VAR:411v1] [HSA:411] [KO:K01135]
  Pathway
hsa00531  Glycosaminoglycan degradation
hsa04142  Lysosome
  Network
nt06012  Glycosaminoglycan degradation
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AB Enzymes
     A16AB08 Galsulfase
      D06565  Galsulfase (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Genetic, Enzyme, or Protein Disorder: Replacement, Modifiers, Treatment
  Galsulfase
   D06565  Galsulfase (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   395  Enzyme preparations
    3959  Others
     D06565  Galsulfase (USAN/INN); Galsulfase (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Sulfatases
    ARSB* [HSA_VAR:411v1]
     D06565  Galsulfase (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D06565
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D06565
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D06565
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D06565
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D06565
Other DBs
CAS: 552858-79-4
PubChem: 47208221
LinkDB

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