KEGG   DRUG: SenicapocHelp
Entry
D06640                      Drug                                   

Name
Senicapoc (USAN)
Formula
C20H15F2NO
Exact mass
323.1122
Mol weight
323.336
Structure
Mol fileKCF fileDB search
Efficacy
Anti-anemic (sickle cell), Potassium intermediate/small conductance calcium-activated channel antagonist
Comment
Treatment of disorders mediated by a calcium activated intermediate conductance potassium ion channel antagonist
Target
KCNN4 [HSA:3783] [KO:K04945]
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Potassium channels
    KCNN4
     D06640  Senicapoc (USAN)
BRITE hierarchy
Other DBs
CAS: 289656-45-7
PubChem: 47208291
ChEMBL: CHEMBL405821
LigandBox: D06640
LinkDB All DBs
KCF data Show

ATOM        24
            1   C8x C    14.4452  -16.1718
            2   C8y C    13.7470  -17.3853
            3   C8x C    14.4488  -18.5967
            4   C8x C    15.8488  -18.5947
            5   C8y C    16.5470  -17.3812
            6   C8x C    15.8452  -16.1698
            7   C1d C    17.9687  -17.3790
            8   C8y C    19.3493  -17.3768
            9   C5a C    17.9665  -15.9806
            10  C8y C    17.9709  -18.7804
            11  C8x C    20.0421  -18.5726
            12  C8x C    21.4421  -18.5706
            13  C8y C    22.1403  -17.3572
            14  C8x C    21.4476  -16.1613
            15  C8x C    20.0476  -16.1634
            16  C8x C    16.7618  -19.4810
            17  C8x C    16.7640  -20.8810
            18  C8x C    17.9775  -21.5791
            19  C8x C    19.1866  -20.8785
            20  C8x C    19.1845  -19.4785
            21  X   F    12.3470  -17.3873
            22  X   F    23.5515  -17.3550
            23  O5a O    16.7682  -15.2909
            24  N1a N    19.2108  -15.2599
BOND        26
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     7   9 1
            10    7  10 1
            11    8  11 2
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16    8  15 1
            17   10  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   10  20 1
            23    2  21 1
            24   13  22 1
            25    9  23 2
            26    9  24 1

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