KEGG   DRUG: Pegfilgrastim
Entry
D06889                      Drug                                   
Name
Pegfilgrastim (USAN/INN);
Pegfilgrastim (genetical recombination) (JAN);
Pegfilgrastim (genetical recombination) [Pegfilgrastim biosimilar 1] (JAN);
Pegfilgrastim-cbqv;
Pegfilgrastim-bmez;
Pegfilgrastim-fpgk;
Neulasta (TN);
G-lasta (TN);
Stimufend (TN);
Udenyca (TN)
Product
FULPHILA (Biocon Biologics), FULPHILA (Mylan Institutional LLC), FYLNETRA (Amneal Pharmaceuticals LLC), NEULASTA (Amgen), NYVEPRIA (Pfizer Laboratories Div Pfizer), STIMUFEND (Fresenius Kabi USA), UDENYCA (Coherus BioSciences), ZIEXTENZO (Sandoz)
Formula
C849H1347N223O244S9. (C2H4O)n
Sequence
MTPLGPASSL PQSFLLKCLE QVRKIQGDGA ALQEKLCATY KLCHPEELVL LGHSLGIPWA
PLSSCPSQAL QLAGCLSQLH SGLFLYQGLL QALEGISPEL GPTLDTLQLD VADFATTIWQ
QMEELGMAPA LQPTQGAMPA FASAFQRRAG GVLVASHLQS FLEVSYRVLR HLAQP
(Disulfide bridge: 37-43, 65-75)
  Type
Peptide
Class
Immunological agent
 DG01753  Colony stimulating factor
  DG01781  Granulocyte colony stimulating factor (G-CSF)
Remark
Therapeutic category: 3399
ATC code: L03AA13
Product: D06889<JP/US>
Efficacy
Antineutropenic, Hematopoietic stimulant, Granulocyte colony stimulating factor (G-CSF)
  Disease
Febrile neutropenia [DS:H00100]
Comment
recombinant granulocyte colony stimulating factor (G-CSF) [HSA:1440] [KO:K05423]
Target
CSF3R (GCSFR, CD114) [HSA:1441] [KO:K05061]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04640  Hematopoietic cell lineage
hsa05200  Pathways in cancer
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L03 IMMUNOSTIMULANTS
   L03A IMMUNOSTIMULANTS
    L03AA Colony stimulating factors
     L03AA13 Pegfilgrastim
      D06889  Pegfilgrastim (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Immunological Agents
  Immunostimulants
   Colony-stimulating Factors
    Pegfilgrastim
     D06889  Pegfilgrastim (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D06889  Pegfilgrastim (USAN/INN); Pegfilgrastim (genetical recombination) (JAN); Pegfilgrastim (genetical recombination) [Pegfilgrastim biosimilar 1] (JAN)
Drug groups [BR:br08330]
 Immunological agent
  DG01753  Colony stimulating factor
   DG01781  Granulocyte colony stimulating factor (G-CSF)
    D06889  Pegfilgrastim
Drug classes [BR:br08332]
 Immunological agent
  DG01753  Colony stimulating factor
   D06889  Pegfilgrastim
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   CSF and other factor receptors
    CSF3R (GCSFR, CD114)
     D06889  Pegfilgrastim (USAN/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D06889
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D06889
Other DBs
CAS: 208265-92-3
PubChem: 49661789
LinkDB

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