KEGG   DRUG: Succinylsulfathiazole
Entry
D07060                      Drug                                   
Name
Succinylsulfathiazole (INN)
Formula
C13H13N3O5S2
Exact mass
355.0297
Mol weight
355.3894
Structure
Simcomp
Class
Antibacterial
 DG01787  Sulfonamide antibacterial
  DG01784  Short-acting sulfonamide
Remark
Same as: C11745
ATC code: A07AB04
Chemical structure group: DG00088
Efficacy
Antibacterial, Folic acid biosynthesis inhibitor
Comment
Sulfonamide
Active form of prodrug: Sulfathiazole [DR:D01047]
Target
dihydropteroate synthase [KO:K00796]
  Pathway
ko00790  Folate biosynthesis
Interaction
Structure map
map07016  Sulfonamide derivatives - sulfa drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07A INTESTINAL ANTIINFECTIVES
    A07AB Sulfonamides
     A07AB04 Succinylsulfathiazole
      D07060  Succinylsulfathiazole (INN)
Drug groups [BR:br08330]
 Antibacterial
  DG01787  Sulfonamide antibacterial
   DG01784  Short-acting sulfonamide
    DG00088  Succinylsulfathiazole
     D07060  Succinylsulfathiazole
Antimicrobials [BR:br08307]
 Antibacterials
  Folic acid biosynthesis inhibitor
   Short-acting sulfonamide
    D07060  Succinylsulfathiazole (INN)
Prodrugs [br08324.html]
 D07060
Drug groups [BR:br08330]
 Antibacterial
  DG01787  Sulfonamide antibacterial
   DG01784  Short-acting sulfonamide
    DG00088  Succinylsulfathiazole
Prodrugs [br08324.html]
 DG00088
Other DBs
CAS: 116-43-8
PubChem: 51091402
ChEBI: 9309
LigandBox: D07060
NIKKAJI: J5.280I
LinkDB
KCF data

ATOM        23
            1   O6a O    15.4700  -26.3200
            2   C6a C    16.6824  -27.0200
            3   C1b C    17.8779  -26.3296
            4   O6a O    16.6825  -28.4198
            5   C1b C    19.0653  -27.0151
            6   C5a C    20.2565  -26.3271
            7   N1b N    21.4460  -27.0138
            8   O5a O    20.2565  -24.9203
            9   C8y C    22.6361  -26.3265
            10  C8x C    23.8262  -27.0135
            11  C8x C    25.0386  -26.3134
            12  C8y C    25.0385  -24.9134
            13  C8x C    23.8485  -24.2264
            14  C8x C    22.6361  -24.9265
            15  S4a S    26.2640  -24.2056
            16  N1b N    27.4721  -24.9029
            17  O3c O    27.4596  -23.5151
            18  C8y C    28.7135  -24.3358
            19  N5x N    30.0218  -24.7704
            20  C8x C    30.8394  -23.6604
            21  C8x C    30.0364  -22.5398
            22  S2x S    28.7226  -22.9572
            23  O3c O    25.2028  -23.2908
BOND        24
            1     1   2 1
            2     2   3 1
            3     2   4 2
            4     3   5 1
            5     5   6 1
            6     6   7 1
            7     6   8 2
            8     7   9 1
            9     9  10 2
            10   10  11 1
            11   11  12 2
            12   12  13 1
            13   13  14 2
            14    9  14 1
            15   12  15 1
            16   15  16 1
            17   15  17 2
            18   16  18 1
            19   18  19 2
            20   19  20 1
            21   20  21 2
            22   21  22 1
            23   18  22 1
            24   15  23 2

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KEGG   DRUG: Succinylsulfathiazole
Entry
D02447                      Drug                                   
Name
Succinylsulfathiazole;
Succinylsulfathiazole monohydrate;
Sulfasuxidine (TN)
Formula
C13H13N3O5S2. H2O
Exact mass
373.0402
Mol weight
373.4047
Structure
Simcomp
Class
Antibacterial
 DG01787  Sulfonamide antibacterial
  DG01784  Short-acting sulfonamide
Remark
ATC code: A07AB04
Chemical structure group: DG00088
Efficacy
Antibacterial, Folic acid biosynthesis inhibitor
Comment
Sulfonamide
Active form of prodrug: Sulfathiazole [DR:D01047]
Target
dihydropteroate synthase [KO:K00796]
  Pathway
ko00790  Folate biosynthesis
Interaction
Structure map
map07016  Sulfonamide derivatives - sulfa drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07A INTESTINAL ANTIINFECTIVES
    A07AB Sulfonamides
     A07AB04 Succinylsulfathiazole
      D02447  Succinylsulfathiazole
Drug groups [BR:br08330]
 Antibacterial
  DG01787  Sulfonamide antibacterial
   DG01784  Short-acting sulfonamide
    DG00088  Succinylsulfathiazole
     D02447  Succinylsulfathiazole
Antimicrobials [BR:br08307]
 Antibacterials
  Folic acid biosynthesis inhibitor
   Short-acting sulfonamide
    D02447  Succinylsulfathiazole
Drug groups [BR:br08330]
 Antibacterial
  DG01787  Sulfonamide antibacterial
   DG01784  Short-acting sulfonamide
    DG00088  Succinylsulfathiazole
Prodrugs [br08324.html]
 DG00088
Other DBs
CAS: 6101-17-3
PubChem: 7849505
LigandBox: D02447
LinkDB
KCF data

ATOM        24
            1   C1b C    13.0356  -17.4752
            2   C5a C    14.2420  -16.7670
            3   N1b N    15.4484  -17.5274
            4   O5a O    14.2304  -15.3752
            5   C8y C    16.7130  -16.8482
            6   C8x C    16.7539  -15.4562
            7   C8x C    17.8674  -17.5563
            8   C8x C    17.8965  -14.7724
            9   C8x C    19.0727  -16.8715
            10  C8y C    19.0200  -15.4853
            11  S4a S    20.3024  -14.8073
            12  N1b N    21.4973  -15.5084
            13  O3c O    19.3056  -13.8036
            14  O3c O    21.4973  -14.0933
            15  C1b C    11.8242  -16.7813
            16  C6a C    10.6201  -17.4879
            17  O6a O     9.4084  -16.8015
            18  O6a O    10.6270  -18.8886
            19  C8y C    22.7298  -14.8087
            20  S2x S    23.8736  -15.6317
            21  C8x C    25.0136  -14.7974
            22  C8x C    24.5723  -13.4554
            23  N5x N    23.1596  -13.4603
            24  O0  O    27.9386  -16.0688
BOND        24
            1     3   5 1
            2     5   6 2
            3     5   7 1
            4     6   8 1
            5     7   9 2
            6     8  10 2
            7    10  11 1
            8    11  12 1
            9    11  13 2
            10   11  14 2
            11    9  10 1
            12    1  15 1
            13    1   2 1
            14   15  16 1
            15    2   3 1
            16    2   4 2
            17   16  17 1
            18   16  18 2
            19   12  19 1
            20   19  20 1
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   19  23 2

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