KEGG   DRUG: Carglumic acid
Entry
D07130                      Drug                                   
Name
Carglumic acid (JAN/USAN/INN);
Carbaglu (TN)
Product
  Generic
Formula
C6H10N2O5
Exact mass
190.0590
Mol weight
190.15
Structure
Simcomp
Remark
Same as: C05829
Therapeutic category: 3999
ATC code: A16AA05
Product: D07130<JP/US>
Efficacy
Antihyperammonemic, CPS1 activator
  Disease
NAGS deficiency [DS:H01032]
Comment
N-acetylglutamate [CPD:C00624] analog
Treatment of hyperammonaemia due to N-acetylglutamate synthase (NAGS) deficiency
Target
CPS1 [HSA:1373] [KO:K01948]
  Pathway
hsa00220  Arginine biosynthesis
hsa00250  Alanine, aspartate and glutamate metabolism
hsa00910  Nitrogen metabolism
  Network
nt06010  Urea cycle
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AA Amino acids and derivatives
     A16AA05 Carglumic acid
      D07130  Carglumic acid (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Electrolytes/Minerals/Metals/Vitamins
  Electrolyte/Mineral Replacement
   Carglumic  Acid
    D07130  Carglumic acid (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D07130  Carglumic acid (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Ligases (EC6)
   Carbamoyl-phosphate synthase
    CPS1
     D07130  Carglumic acid (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D07130
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D07130
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D07130
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D07130
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D07130
Other DBs
CAS: 1188-38-1
PubChem: 51091469
ChEBI: 71028
LigandBox: D07130
LinkDB
KCF data

ATOM        13
            1   O6a O    23.7300  -15.7500
            2   C6a C    22.5400  -15.0500
            3   C1b C    21.2800  -15.7500
            4   C1b C    20.0900  -15.0500
            5   C1c C    18.9000  -15.7500
            6   C6a C    17.6400  -15.0500
            7   O6a O    16.4500  -15.7500
            8   O6a O    22.5400  -13.6500
            9   O6a O    17.6400  -13.6500
            10  N1b N    18.9000  -17.1500
            11  C5a C    20.0900  -17.8500
            12  O5a O    20.0900  -19.2500
            13  N1a N    21.2800  -17.1500
BOND        12
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     2   8 2
            8     6   9 2
            9     5  10 1 #Down
            10   10  11 1
            11   11  12 2
            12   11  13 1

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