KEGG   DRUG: TolpropamineHelp
Entry
D07196                      Drug                                   

Name
Tolpropamine (INN)
Formula
C18H23N
Exact mass
253.1831
Mol weight
253.3819
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Remark
ATC code: D04AA12
Efficacy
Antiallergic, H1 receptor antagonist
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA12 Tolpropamine
      D07196  Tolpropamine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D07196  Tolpropamine (INN)
BRITE hierarchy
Other DBs
CAS: 5632-44-0
PubChem: 51091534
ChEMBL: CHEMBL2107261
LigandBox: D07196
NIKKAJI: J8.034I
LinkDB All DBs
KCF data Show

ATOM        19
            1   C8x C    19.6466  -20.3863
            2   C8x C    18.4340  -21.0860
            3   C8x C    17.2329  -20.4051
            4   C8x C    17.2445  -19.0246
            5   C8y C    18.4571  -18.3248
            6   C8x C    19.6581  -19.0057
            7   C1c C    18.4942  -16.8487
            8   C8y C    17.2932  -16.1678
            9   C8x C    16.0200  -16.9025
            10  C8x C    14.8189  -16.2217
            11  C8y C    14.8655  -14.7805
            12  C8x C    16.0687  -14.0458
            13  C8x C    17.3047  -14.7872
            14  C1b C    19.6462  -16.1839
            15  C1b C    20.8823  -16.9254
            16  N1c N    22.0949  -16.2257
            17  C1a C    22.0714  -14.7845
            18  C1a C    23.2959  -16.9065
            19  C1a C    13.5944  -14.0996
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    7  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   16  18 1
            20   11  19 1

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