KEGG   DRUG: FormestaneHelp
Entry
D07260                      Drug                                   

Name
Formestane (INN);
Lentaron (TN)
Formula
C19H26O3
Exact mass
302.1882
Mol weight
302.4079
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antineoplastic
 DG01596  Aromatase inhibitor
Remark
ATC code: L02BG02
Efficacy
Antineoplastic, Estrogen biosynthesis inhibitor
Comment
Aromatase inhibitor
Target
CYP19A1 (ARO) [HSA:1588] [KO:K07434]
  Pathway
hsa00140  Steroid hormone biosynthesis
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L02 ENDOCRINE THERAPY
   L02B HORMONE ANTAGONISTS AND RELATED AGENTS
    L02BG Aromatase inhibitors
     L02BG02 Formestane
      D07260  Formestane (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Cytochrome P450
    CYP19A1 (ARO)
     D07260  Formestane (INN)
BRITE hierarchy
Other DBs
CAS: 566-48-3
PubChem: 51091598
ChEBI: 75172
ChEMBL: CHEMBL132530
LigandBox: D07260
NIKKAJI: J337.162J
LinkDB All DBs
KCF data Show

ATOM        22
            1   C1z C    24.4300  -16.8000
            2   C1y C    24.4300  -18.2000
            3   C1x C    26.8549  -18.2000
            4   C1x C    26.8549  -16.8000
            5   C5x C    25.6424  -16.1000
            6   C1x C    23.2176  -16.1000
            7   C1x C    22.0051  -16.8000
            8   C1y C    22.0051  -18.2000
            9   C1y C    23.2176  -18.9000
            10  C1z C    20.7927  -18.9000
            11  C2y C    20.7927  -20.3000
            12  C1x C    22.0051  -21.0000
            13  C1x C    23.2176  -20.3000
            14  C1x C    19.5803  -18.2000
            15  C1x C    18.3678  -18.9000
            16  C5x C    18.3678  -20.3000
            17  C2y C    19.5803  -21.0000
            18  O5x O    17.1347  -21.0122
            19  O5x O    25.6424  -14.7002
            20  O1a O    19.5803  -22.3999
            21  C1a C    20.7927  -17.5000
            22  C1a C    24.4300  -15.4000
BOND        25
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     1   6 1
            7     6   7 1
            8     7   8 1
            9     8   9 1
            10    9   2 1
            11    8  10 1
            12   10  11 1
            13   11  12 1
            14   12  13 1
            15   13   9 1
            16   10  14 1
            17   14  15 1
            18   15  16 1
            19   16  17 1
            20   17  11 2
            21   16  18 2
            22    5  19 2
            23   17  20 1
            24   10  21 1 #Up
            25    1  22 1 #Up

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