KEGG   DRUG: ChlorphenamineHelp
Entry
D07398                      Drug                                   

Name
Chlorphenamine (INN);
Chlorpheniramine;
Clofeniramina (TN)
Formula
C16H19ClN2
Exact mass
274.1237
Mol weight
274.7885
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Enzyme substrate
 DG01644  CYP2D6 substrate
Enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Same as: C06905
ATC code: R06AB04
Chemical structure group: DG01099
Product (DG01099): D00665<JP>
Product (mixture): D11075<US>
Efficacy
Antiallergic, H1 receptor antagonist
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Interaction
Drug interaction
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AB Substituted alkylamines
     R06AB04 Chlorphenamine
      D07398  Chlorphenamine (INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D07398  Chlorphenamine (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Chlorphenamine
    D07398  Chlorphenamine (INN)
 Third-class OTC drugs
  Inorganic and organic chemicals
   Chlorphenamine
    D07398  Chlorphenamine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D07398  Chlorphenamine (INN)
BRITE hierarchy
Other DBs
CAS: 132-22-9
PubChem: 51091734
ChEBI: 52010
ChEMBL: CHEMBL505
LigandBox: D07398
NIKKAJI: J5.570K
LinkDB All DBs
KCF data Show

ATOM        19
            1   C8x C    13.8600  -15.8900
            2   C8y C    13.8600  -17.2900
            3   C8x C    15.0724  -17.9900
            4   C8x C    16.2849  -17.2900
            5   C8y C    16.2849  -15.8900
            6   C8x C    15.0724  -15.1900
            7   C1c C    17.5160  -15.1790
            8   C8y C    18.7212  -15.8747
            9   C8x C    18.7216  -17.2896
            10  C8x C    19.9342  -17.9893
            11  C8x C    21.1465  -17.2889
            12  C8x C    21.1460  -15.8739
            13  N5x N    19.9334  -15.1743
            14  C1b C    17.5157  -13.7901
            15  C1b C    18.7281  -13.0901
            16  N1c N    18.7281  -11.6901
            17  C1a C    19.9643  -10.9760
            18  C1a C    17.5397  -11.0038
            19  X   Cl   12.6476  -17.9900
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    7  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   16  18 1
            20    2  19 1

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