KEGG   DRUG: ParomomycinHelp
Entry
D07467                      Drug                                   

Name
Paromomycin (INN);
PRM;
Paromomycin (TN)
Formula
C23H45N5O14
Exact mass
615.2963
Mol weight
615.6285
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Source
Streptomyces chrestomyceticus [TAX:68185]
Class
Antibacterial
 DG01447  Aminoglycoside antibiotic
Remark
Same as: C00832
ATC code: A07AA06
Chemical structure group: DG00084
Product (DG00084): D00868<JP/US>
Efficacy
Antibiotic, Amebicide, Protein biosynthesis inhibitor
Target
30S ribosomal subunit
  Pathway
ko03010  Ribosome
Interaction
Drug interaction
Biosynthesis
map00524  Neomycin, kanamycin and gentamicin biosynthesis
Structure map
map07021  Aminoglycosides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07A INTESTINAL ANTIINFECTIVES
    A07AA Antibiotics
     A07AA06 Paromomycin
      D07467  Paromomycin (INN)
USP drug classification [BR:br08302]
 Antibacterials
  Aminoglycosides
   Paromomycin
    D07467  Paromomycin (INN)
BRITE hierarchy
Other DBs
CAS: 7542-37-2
PubChem: 96024433
ChEBI: 7934
ChEMBL: CHEMBL370143
DrugBank: DB01421
PDB-CCD: PAR[PDBj]
LigandBox: D07467
NIKKAJI: J8.952D
LinkDB All DBs
KCF data Show

ATOM        42
            1   C1y C    17.7100  -20.7900
            2   C1y C    17.7100  -22.1900
            3   C1y C    18.9000  -22.8900
            4   C1y C    20.0900  -22.1900
            5   C1y C    20.0900  -20.7900
            6   O2x O    18.9000  -20.0900
            7   O2a O    21.2800  -20.0900
            8   C1y C    23.5200  -18.9700
            9   C1y C    23.9400  -17.6400
            10  O2x O    22.8200  -16.8000
            11  C1y C    21.7000  -17.6400
            12  C1y C    22.1200  -18.9700
            13  O2a O    25.4800  -17.2200
            14  O1a O    25.8300  -20.0200
            15  C1y C    27.0200  -19.3200
            16  C1y C    28.2100  -19.9500
            17  C1x C    29.4000  -19.2500
            18  C1y C    29.4000  -17.8500
            19  C1y C    28.2100  -17.2200
            20  C1y C    27.0200  -17.9200
            21  N1a N    28.2100  -21.3500
            22  N1a N    30.5900  -17.1500
            23  O2a O    28.2100  -15.8200
            24  C1y C    29.4000  -15.1200
            25  O2x O    30.5900  -15.8200
            26  C1y C    31.8500  -15.1200
            27  C1y C    31.8500  -13.7200
            28  C1y C    30.5900  -13.0200
            29  C1y C    29.4000  -13.7200
            30  C1b C    32.9700  -15.7500
            31  O1a O    33.0400  -17.1500
            32  N1a N    28.2100  -13.0200
            33  O1a O    30.5900  -11.6200
            34  O1a O    32.9700  -13.0200
            35  C1b C    20.3700  -17.2200
            36  O1a O    24.2900  -20.0900
            37  O1a O    19.3200  -18.1300
            38  C1b C    16.5200  -20.0900
            39  O1a O    16.5200  -22.8900
            40  N1a N    21.2800  -22.8900
            41  O1a O    18.9000  -24.2200
            42  N1a N    15.2600  -20.7900
BOND        45
            1    19  23 1 #Down
            2    20  13 1 #Up
            3    10  11 1
            4    24  23 1 #Down
            5    11  12 1
            6    12   8 1
            7     5   6 1
            8     9  13 1 #Up
            9     6   1 1
            10   24  25 1
            11   25  26 1
            12   26  27 1
            13   27  28 1
            14   28  29 1
            15   29  24 1
            16   26  30 1 #Up
            17   15  14 1 #Down
            18   30  31 1
            19    5   7 1 #Down
            20   29  32 1 #Down
            21   28  33 1 #Up
            22    1   2 1
            23   27  34 1 #Down
            24    2   3 1
            25   11  35 1 #Up
            26   12   7 1 #Down
            27    3   4 1
            28    8  36 1 #Down
            29   15  16 1
            30   35  37 1
            31   16  17 1
            32    1  38 1 #Down
            33   17  18 1
            34    2  39 1 #Down
            35   18  19 1
            36    4  40 1 #Down
            37   19  20 1
            38    3  41 1 #Up
            39   20  15 1
            40   38  42 1
            41    4   5 1
            42   16  21 1 #Up
            43    8   9 1
            44   18  22 1 #Up
            45    9  10 1

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