| Entry |
|
|---|
| Name |
Azithromycin (INN);
Azasite (TN);
Azithromycin (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C38H72N2O12
|
|---|
| Exact mass |
748.5085
|
|---|
| Mol weight |
748.98
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antibacterial
DG01551 Macrolide antibiotic
DG01875 15-Membered ring macrolide antibiotic
Transporter substrate
DG01665 ABCB1 substrate
Transporter inhibitor
DG01622 ABCB1 inhibitor
|
|---|
| Remark |
| Product (DG00606): | D07486<US> D02134<JP/US> D06390<US> |
|
|---|
| Efficacy |
Antibacterial, Protein biosynthesis inhibitor |
|---|
| Disease |
Urethritis and cervicitis due to Chlamydia trachomatis [DS: H00347] |
|---|
| Target |
50S ribosomal subunit |
|---|
| Pathway |
|
|---|
| Metabolism |
Transporter: ABCB1 [HSA: 5243]
|
|---|
| Interaction |
Transporter inhibition: ABCB1 [HSA: 5243]
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
J01FA Macrolides
J01FA10 Azithromycin
D07486 Azithromycin (INN) <US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01A ANTIINFECTIVES
S01AA Antibiotics
S01AA26 Azithromycin
D07486 Azithromycin (INN) <US>
USP drug classification [BR:br08302]
Antibacterials
Macrolides
Azithromycin
D07486 Azithromycin (INN)
Ophthalmic Agents
Ophthalmic Anti-Infectives
Antibacterials, Ophthalmic
Azithromycin
D07486 Azithromycin (INN)
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01875 15-Membered ring macrolide antibiotic
DG00606 Azithromycin
D07486 Azithromycin
Transporter substrate
DG01665 ABCB1 substrate
DG00606 Azithromycin
D07486 Azithromycin
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG00606 Azithromycin
D07486 Azithromycin
Drug classes [BR:br08332]
Antibacterial
DG01551 Macrolide antibiotic
D07486 Azithromycin
Antimicrobials [BR:br08307]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
D07486 Azithromycin (INN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D07486
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01875 15-Membered ring macrolide antibiotic
DG00606 Azithromycin
Transporter substrate
DG01665 ABCB1 substrate
DG00606 Azithromycin
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG00606 Azithromycin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
DG00606 Azithromycin
|
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| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 52
1 C1y C 17.9900 -14.2100
2 C1y C 16.7300 -14.8400
3 O2a O 19.5300 -15.1900
4 C1z C 17.9900 -12.8800
5 C1y C 16.7300 -16.1700
6 C1a C 15.9600 -13.8600
7 C1y C 20.8600 -14.4200
8 C1x C 17.2200 -12.3200
9 C1a C 19.1800 -13.4400
10 O1a O 19.1800 -12.1800
11 O2a O 17.5000 -18.1300
12 C1y C 15.6100 -16.8000
13 C1y C 21.6300 -15.6800
14 O2x O 21.6300 -13.1600
15 C1y C 17.7100 -11.0600
16 C1y C 19.1100 -18.8300
17 C7x C 14.4900 -16.1700
18 C1a C 15.5400 -18.1300
19 C1y C 23.0300 -15.6800
20 O1a O 20.8600 -16.9400
21 C1y C 23.0300 -13.1600
22 C1x C 16.8700 -10.2200
23 C1a C 18.6900 -10.5000
24 C1x C 19.1100 -20.3000
25 O2x O 20.3700 -18.1300
26 O7x O 14.4900 -14.8400
27 O6a O 13.5100 -17.1500
28 C1x C 23.7300 -14.4200
29 N1c N 23.7300 -16.9400
30 C1a C 23.7300 -11.9700
31 N1y N 15.6800 -10.2200
32 C1z C 20.3700 -21.0000
33 C1y C 21.5600 -18.8300
34 C1y C 13.3700 -14.1400
35 C1a C 25.1300 -17.8500
36 C1a C 25.0600 -16.2400
37 C1y C 14.5600 -10.8500
38 C1a C 15.6800 -8.8900
39 C1y C 21.5600 -20.3000
40 O2a O 20.3000 -22.3300
41 C1a C 22.8200 -18.1300
42 C1z C 13.3700 -12.8100
43 C1b C 12.1800 -14.7700
44 C1y C 14.5600 -12.1800
45 C1a C 13.3700 -10.1500
46 O1a O 22.8200 -21.0000
47 C1a C 21.4900 -23.0300
48 C1a C 12.0400 -13.3000
49 O1a O 12.1800 -11.6900
50 C1a C 12.1800 -16.1000
51 O1a O 15.6800 -12.8800
52 C1a C 19.1100 -21.7000
BOND 54
1 1 2 1
2 1 3 1 #Down
3 1 4 1
4 2 5 1
5 2 6 1 #Down
6 7 3 1 #Down
7 4 8 1
8 4 9 1 #Down
9 4 10 1 #Up
10 5 11 1 #Down
11 5 12 1
12 7 13 1
13 7 14 1
14 8 15 1
15 16 11 1 #Down
16 12 17 1
17 12 18 1 #Up
18 13 19 1
19 13 20 1 #Up
20 14 21 1
21 15 22 1
22 15 23 1 #Down
23 16 24 1
24 16 25 1
25 17 26 1
26 17 27 2
27 19 28 1
28 19 29 1 #Down
29 21 30 1 #Down
30 22 31 1
31 24 32 1
32 25 33 1
33 26 34 1
34 29 35 1
35 29 36 1
36 31 37 1
37 31 38 1
38 32 39 1
39 32 40 1 #Down
40 33 41 1 #Up
41 34 42 1
42 34 43 1 #Down
43 37 44 1
44 37 45 1 #Up
45 39 46 1 #Down
46 40 47 1
47 42 48 1 #Down
48 42 49 1 #Up
49 43 50 1
50 44 51 1 #Up
51 21 28 1
52 33 39 1
53 42 44 1
54 32 52 1 #Up
|
|---|
