KEGG   DRUG: Carbinoxamine
Entry
D07617                      Drug                                   

Name
Carbinoxamine (INN)
Formula
C16H19ClN2O
Exact mass
290.1186
Mol weight
290.7879
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Remark
Same as: C06871
ATC code: R06AA08
Chemical structure group: DG01095
Product (DG01095): D01336<US>
Efficacy
Antiallergic, H1 receptor antagonist
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Interaction
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AA Aminoalkyl ethers
     R06AA08 Carbinoxamine
      D07617  Carbinoxamine (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Carbinoxamine
    D07617  Carbinoxamine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D07617  Carbinoxamine (INN)
Other DBs
CAS: 486-16-8
PubChem: 51091926
ChEBI: 3398
ChEMBL: CHEMBL864
DrugBank: DB00748
LigandBox: D07617
NIKKAJI: J6.006B
LinkDB
KCF data

ATOM        20
            1   C8x C    27.7900  -18.9700
            2   C8x C    27.7900  -20.3700
            3   C8x C    26.6000  -21.0700
            4   C8x C    25.3400  -20.3700
            5   C8y C    25.3400  -18.9700
            6   N5x N    26.6000  -18.2700
            7   C8x C    22.9600  -20.3700
            8   C8y C    22.9600  -18.9700
            9   C1c C    24.1500  -18.2700
            10  C8x C    21.7000  -21.0700
            11  C8y C    20.5100  -20.3700
            12  C8x C    20.5100  -18.9700
            13  C8x C    21.7000  -18.2700
            14  X   Cl   19.3200  -21.0700
            15  O2a O    24.1500  -16.8700
            16  C1b C    25.4100  -16.1700
            17  C1b C    26.6000  -16.8700
            18  N1c N    27.7900  -16.1700
            19  C1a C    28.9800  -16.8700
            20  C1a C    27.7900  -14.7700
BOND        21
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15   11  14 1
            16    9  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   18  20 1

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KEGG   DRUG: Carbinoxamine maleate
Entry
D01336                      Drug                                   

Name
Carbinoxamine maleate (JAN/USP);
Clistin (TN);
Karbinal er (TN)
Product
  Generic
Formula
C16H19ClN2O. C4H4O4
Exact mass
406.1296
Mol weight
406.86
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Remark
ATC code: R06AA08
Chemical structure group: DG01095
Product (DG01095): D01336<US>
Efficacy
Antiallergic, H1 receptor antagonist
  Disease
Allergic rhinitis [DS:H01360]
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Interaction
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AA Aminoalkyl ethers
     R06AA08 Carbinoxamine
      D01336  Carbinoxamine maleate (JAN/USP) <US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Histamine (H1) Receptor Antagonists, Sedating
    Carbinoxamine
     D01336  Carbinoxamine maleate (JAN/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for otolaryngologic use
  69 Oral medicine for nasal inflammation
   D01336  Carbinoxamine maleate (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Carbinoxamine
    D01336  Carbinoxamine maleate (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D01336  Carbinoxamine maleate (JAN/USP) <US>
Other DBs
CAS: 3505-38-2
PubChem: 7848399
ChEBI: 31353
ChEMBL: CHEMBL1200974
DrugBank: DB00748
LigandBox: D01336
NIKKAJI: J383.157D
LinkDB
KCF data

ATOM        28
            1   C6a C    34.1191  -18.0091
            2   C2b C    33.4156  -16.8836
            3   O6a O    33.4156  -19.2049
            4   O6a O    35.4556  -18.0091
            5   C2b C    31.7977  -16.8836
            6   C6a C    31.0942  -18.0091
            7   O6a O    29.7577  -18.0091
            8   O6a O    31.7977  -19.2049
            9   C8x C    19.9093  -17.0242
            10  C8y C    19.9093  -18.4311
            11  C8x C    21.1277  -19.1346
            12  C8x C    22.3462  -18.4311
            13  C8y C    22.3462  -17.0242
            14  C8x C    21.1277  -16.3208
            15  C8x C    24.7830  -18.4311
            16  C8y C    24.7830  -17.0242
            17  C1c C    23.5646  -16.3208
            18  C8x C    26.0014  -19.1346
            19  C8x C    27.2198  -18.4311
            20  C8x C    27.2198  -17.0242
            21  N5x N    26.0014  -16.3208
            22  X   Cl   18.6910  -19.1346
            23  O2a O    23.5646  -14.9139
            24  C1b C    24.7851  -14.2092
            25  C1b C    25.9875  -14.9036
            26  N1c N    27.1801  -14.2151
            27  C1a C    28.3775  -14.9066
            28  C1a C    27.1803  -12.8037
BOND        28
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     5   6 1
            6     6   7 1
            7     6   8 2
            8     9  10 2
            9    10  11 1
            10   11  12 2
            11   12  13 1
            12   13  14 2
            13    9  14 1
            14   15  16 1
            15   16  17 1
            16   13  17 1
            17   15  18 2
            18   18  19 1
            19   19  20 2
            20   20  21 1
            21   16  21 2
            22   10  22 1
            23   17  23 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   26  27 1
            28   26  28 1

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