KEGG   DRUG: CortisoneHelp
Entry
D07749                      Drug                                   

Name
Cortisone (INN);
Cortisone (TN)
Formula
C21H28O5
Exact mass
360.1937
Mol weight
360.444
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Enzyme substrate
 DG01633  CYP3A substrate
Remark
Same as: C00762
ATC code: H02AB10 S01BA03
Chemical structure group: DG00509
Product (DG00509): D00973<JP/US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB10 Cortisone
      D07749  Cortisone (INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA03 Cortisone
      D07749  Cortisone (INN)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Cortisone
   D07749  Cortisone (INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Cortisone
    D07749  Cortisone (INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D07749  Cortisone (INN)
BRITE hierarchy
Other DBs
CAS: 53-06-5
PubChem: 51092041
ChEBI: 16962
ChEMBL: CHEMBL1499 CHEMBL536
LigandBox: D07749
NIKKAJI: J4.139D
LinkDB All DBs
KCF data Show

ATOM        26
            1   C1x C    20.0900  -19.4600
            2   C5x C    20.0900  -20.7900
            3   C2x C    21.2800  -21.4900
            4   C2y C    22.4000  -20.7900
            5   C1z C    22.4000  -19.4600
            6   C1x C    21.2800  -18.7600
            7   C1x C    23.5900  -21.4900
            8   C1x C    24.7800  -20.7900
            9   C1y C    24.7800  -19.4600
            10  C1y C    23.5900  -18.7600
            11  C1y C    25.9700  -18.7600
            12  C1z C    25.9700  -17.4300
            13  C1x C    24.7800  -16.7300
            14  C5x C    23.5900  -17.4300
            15  C1x C    28.2800  -18.7600
            16  C1x C    28.2800  -17.4300
            17  C1z C    27.1600  -16.7300
            18  C1a C    22.4000  -18.0600
            19  C1a C    25.9700  -16.0300
            20  C5a C    27.1600  -15.0500
            21  O5x O    18.9000  -21.4900
            22  O5x O    22.4000  -16.7300
            23  C1b C    28.3500  -14.3500
            24  O5a O    25.9700  -14.3500
            25  O1a O    28.2800  -16.0300
            26  O1a O    29.4700  -14.9800
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   12  19 1 #Up
            23   17  20 1 #Up
            24    2  21 2
            25   14  22 2
            26   20  23 1
            27   20  24 2
            28   17  25 1 #Down
            29   23  26 1

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