KEGG   DRUG: DextropropoxypheneHelp
Entry
D07809                      Drug                                   

Name
Dextropropoxyphene (INN);
Propoxypene
Formula
C22H29NO2
Exact mass
339.2198
Mol weight
339.4712
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Remark
Same as: C07406
ATC code: N02AC04
Chemical structure group: DG00818
Efficacy
Analgesic, Opioid receptor agonist
Comment
Diphenylpropylamine derivative
semi-synthetic opioids
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AC Diphenylpropylamine derivatives
     N02AC04 Dextropropoxyphene
      D07809  Dextropropoxyphene (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D07809  Dextropropoxyphene (INN)
BRITE hierarchy
Other DBs
CAS: 469-62-5
PubChem: 96024506
ChEBI: 51173
ChEMBL: CHEMBL1201790 CHEMBL1213351
DrugBank: DB00647
LigandBox: D07809
NIKKAJI: J5.928E
LinkDB All DBs
KCF data Show

ATOM        25
            1   C8x C    15.7997  -19.1502
            2   C8x C    16.4991  -20.4090
            3   C8x C    17.8977  -20.4090
            4   C8x C    18.5970  -19.1502
            5   C8y C    17.8977  -17.9613
            6   C8x C    16.4991  -17.9613
            7   C8x C    19.9957  -19.1502
            8   C8y C    20.6950  -17.9613
            9   C1b C    19.9957  -16.7726
            10  C1d C    18.5970  -16.7726
            11  C8x C    20.6950  -20.4090
            12  C8x C    22.0937  -20.4090
            13  C8x C    22.7930  -19.1502
            14  C8x C    22.0937  -17.9613
            15  O7a O    17.8977  -15.5837
            16  C7a C    16.4991  -15.5837
            17  C1b C    15.7997  -14.3949
            18  C1a C    14.4011  -14.3949
            19  O6a O    15.7997  -16.7726
            20  C1c C    19.2964  -15.5138
            21  C1a C    20.6950  -15.5138
            22  C1b C    18.5970  -14.3249
            23  N1c N    19.2964  -13.1361
            24  C1a C    20.6950  -13.1361
            25  C1a C    18.5970  -11.8773
BOND        26
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9    10   9 1 #Down
            10   10   5 1 #Up
            11    7  11 2
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15    8  14 2
            16   10  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   16  19 2
            21   10  20 1
            22   20  21 1 #Up
            23   20  22 1
            24   22  23 1
            25   23  24 1
            26   23  25 1

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