KEGG   DRUG: Dextropropoxyphene
Entry
D07809                      Drug                                   
Name
Dextropropoxyphene (INN);
Propoxypene
Formula
C22H29NO2
Exact mass
339.2198
Mol weight
339.47
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Remark
Same as: C07406
ATC code: N02AC04
Chemical structure group: DG00818
Product (DG00818): D00482<US>
Efficacy
Analgesic, Opioid receptor agonist
Comment
Diphenylpropylamine derivative
semi-synthetic opioids
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AC Diphenylpropylamine derivatives
     N02AC04 Dextropropoxyphene
      D07809  Dextropropoxyphene (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00818  Dextropropoxyphene
     D07809  Dextropropoxyphene
 Analgesic
  DG01984  Opioid analgesics
   DG00818  Dextropropoxyphene
    D07809  Dextropropoxyphene
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D07809  Dextropropoxyphene (INN)
Narcotics and psychotropics in Japan [br08308.html]
 Narcotics by Control Act Article 2 Table 1 (74 substances)
  D07809
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00818  Dextropropoxyphene
 Analgesic
  DG01984  Opioid analgesics
   DG00818  Dextropropoxyphene
Other DBs
CAS: 469-62-5
PubChem: 96024506
ChEBI: 51173
LigandBox: D07809
NIKKAJI: J5.928E
LinkDB
KCF data

ATOM        25
            1   C8x C    15.7997  -19.1502
            2   C8x C    16.4991  -20.4090
            3   C8x C    17.8977  -20.4090
            4   C8x C    18.5970  -19.1502
            5   C8y C    17.8977  -17.9613
            6   C8x C    16.4991  -17.9613
            7   C8x C    19.9957  -19.1502
            8   C8y C    20.6950  -17.9613
            9   C1b C    19.9957  -16.7726
            10  C1d C    18.5970  -16.7726
            11  C8x C    20.6950  -20.4090
            12  C8x C    22.0937  -20.4090
            13  C8x C    22.7930  -19.1502
            14  C8x C    22.0937  -17.9613
            15  O7a O    17.8977  -15.5837
            16  C7a C    16.4991  -15.5837
            17  C1b C    15.7997  -14.3949
            18  C1a C    14.4011  -14.3949
            19  O6a O    15.7997  -16.7726
            20  C1c C    19.2964  -15.5138
            21  C1a C    20.6950  -15.5138
            22  C1b C    18.5970  -14.3249
            23  N1c N    19.2964  -13.1361
            24  C1a C    20.6950  -13.1361
            25  C1a C    18.5970  -11.8773
BOND        26
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9    10   9 1 #Down
            10   10   5 1 #Up
            11    7  11 2
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15    8  14 2
            16   10  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   16  19 2
            21   10  20 1
            22   20  21 1 #Up
            23   20  22 1
            24   22  23 1
            25   23  24 1
            26   23  25 1

» Japanese version   » Back

KEGG   DRUG: Propoxyphene hydrochloride
Entry
D00482                      Drug                                   
Name
Propoxyphene hydrochloride (USAN);
Dextropropoxyphene hydrochloride;
Darvon (TN)
Product
  Generic
AMETHIA (Mayne Pharma), LO SIMPESSE (Aurobindo Pharma Limited)
Formula
C22H29NO2. HCl
Exact mass
375.1965
Mol weight
375.93
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Remark
ATC code: N02AC04
Chemical structure group: DG00818
Product (DG00818): D00482<US>
Efficacy
Analgesic, Opioid receptor agonist
Comment
Diphenylpropylamine derivative
Propoxyphene is called Dextropropoxyphene in INN.
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AC Diphenylpropylamine derivatives
     N02AC04 Dextropropoxyphene
      D00482  Propoxyphene hydrochloride (USAN) <US>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00818  Dextropropoxyphene
     D00482  Propoxyphene hydrochloride
 Analgesic
  DG01984  Opioid analgesics
   DG00818  Dextropropoxyphene
    D00482  Propoxyphene hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D00482  Propoxyphene hydrochloride (USAN) <US>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00818  Dextropropoxyphene
 Analgesic
  DG01984  Opioid analgesics
   DG00818  Dextropropoxyphene
Other DBs
CAS: 1639-60-7
PubChem: 7847548
ChEBI: 8498
LigandBox: D00482
NIKKAJI: J388.905J
LinkDB
KCF data

ATOM        26
            1   X   Cl   23.9038  -16.2708
            2   C8x C    14.7259  -19.2286
            3   C8x C    15.4238  -20.4397
            4   C8x C    16.8216  -20.4408
            5   C8x C    17.5215  -19.2309
            6   C8y C    16.8236  -18.0198
            7   C8x C    15.4258  -18.0187
            8   C8x C    18.9192  -19.2320
            9   C8y C    19.6191  -18.0220
            10  C1b C    18.9211  -16.8109
            11  C1d C    17.5234  -16.8098
            12  C8x C    19.6171  -20.4430
            13  C8x C    21.0149  -20.4441
            14  C8x C    21.7148  -19.2342
            15  C8x C    21.0169  -18.0231
            16  O7a O    16.8395  -15.6226
            17  C7a C    15.4474  -15.6215
            18  O6a O    14.7386  -16.8466
            19  C1b C    14.7583  -14.4256
            20  C1a C    13.3509  -14.4243
            21  C1c C    18.2223  -15.5994
            22  C1a C    19.6403  -15.5998
            23  C1b C    17.5168  -14.3775
            24  N1c N    18.2193  -13.1601
            25  C1a C    19.6402  -13.1603
            26  C1a C    17.5113  -11.9347
BOND        26
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     8   9 1
            8     9  10 1
            9    11  10 1 #Down
            10   11   6 1 #Up
            11    8  12 2
            12   12  13 1
            13   13  14 2
            14   14  15 1
            15    9  15 2
            16   11  16 1
            17   16  17 1
            18   17  18 2
            19   17  19 1
            20   19  20 1
            21   11  21 1
            22   21  22 1 #Up
            23   21  23 1
            24   23  24 1
            25   24  25 1
            26   24  26 1

» Japanese version   » Back

KEGG   DRUG: Propoxyphene napsylate
Entry
D05632                      Drug                                   
Name
Propoxyphene napsylate (USAN);
Darvon-N (TN)
Formula
C22H29NO2. C10H8O3S. H2O
Exact mass
565.2498
Mol weight
565.72
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Remark
ATC code: N02AC04
Chemical structure group: DG00818
Product (DG00818): D00482<US>
Efficacy
Analgesic
Comment
Component of Darvocet (TN)
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AC Diphenylpropylamine derivatives
     N02AC04 Dextropropoxyphene
      D05632  Propoxyphene napsylate (USAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00818  Dextropropoxyphene
     D05632  Propoxyphene napsylate
 Analgesic
  DG01984  Opioid analgesics
   DG00818  Dextropropoxyphene
    D05632  Propoxyphene napsylate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D05632  Propoxyphene napsylate (USAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00818  Dextropropoxyphene
 Analgesic
  DG01984  Opioid analgesics
   DG00818  Dextropropoxyphene
Other DBs
CAS: 26570-10-5
PubChem: 47207294
ChEBI: 51179
LigandBox: D05632
LinkDB
KCF data

ATOM        40
            1   C8x C    19.7971  -15.6634
            2   C8x C    19.7971  -17.0592
            3   C8x C    21.0059  -17.7571
            4   C8y C    22.2146  -17.0592
            5   C8y C    22.2146  -15.6634
            6   C8x C    21.0059  -14.9655
            7   C8x C    23.4234  -17.7571
            8   C8x C    24.6322  -17.0592
            9   C8y C    24.6322  -15.6634
            10  C8x C    23.4234  -14.9655
            11  S4a S    25.8261  -14.9739
            12  O1d O    27.0349  -14.2761
            13  O1d O    25.1181  -13.7471
            14  O1d O    26.5133  -16.1646
            15  O0  O    22.8678  -19.6414
            16  C8x C    11.5597  -19.2887
            17  C8x C    12.2574  -20.4748
            18  C8x C    13.6528  -20.4748
            19  C8x C    14.3505  -19.2887
            20  C8y C    13.6528  -18.0329
            21  C8x C    12.2574  -18.0329
            22  C8x C    15.7458  -19.2887
            23  C8y C    16.4435  -18.0329
            24  C1b C    15.7458  -16.8468
            25  C1d C    14.3505  -16.8468
            26  C8x C    16.4435  -20.4748
            27  C8x C    17.8389  -20.4748
            28  C8x C    18.5366  -19.2887
            29  C8x C    17.8389  -18.0329
            30  O7a O    13.7226  -15.6608
            31  C7a C    12.3272  -15.6608
            32  O6a O    11.6295  -16.9166
            33  C1b C    11.6295  -14.4747
            34  C1a C    10.2341  -14.4747
            35  C1c C    15.0482  -15.6608
            36  C1a C    16.5133  -15.6608
            37  C1b C    14.3505  -14.4049
            38  N1c N    15.0482  -13.2189
            39  C1a C    16.5133  -13.2189
            40  C1a C    14.3505  -11.9631
BOND        41
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   11  13 2
            15   11  14 2
            16   16  17 2
            17   17  18 1
            18   18  19 2
            19   19  20 1
            20   20  21 2
            21   16  21 1
            22   22  23 1
            23   23  24 1
            24   25  24 1 #Down
            25   25  20 1 #Up
            26   22  26 2
            27   26  27 1
            28   27  28 2
            29   28  29 1
            30   23  29 2
            31   25  30 1
            32   30  31 1
            33   31  32 2
            34   31  33 1
            35   33  34 1
            36   25  35 1
            37   35  36 1 #Up
            38   35  37 1
            39   37  38 1
            40   38  39 1
            41   38  40 1

» Japanese version   » Back

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