KEGG   DRUG: Pethidine
Entry
D08343                      Drug                                   
Name
Pethidine (INN);
Meperidine;
Pethidine DBL (TN)
Formula
C15H21NO2
Exact mass
247.1572
Mol weight
247.33
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Remark
Same as: C07128
ATC code: N02AB02
Chemical structure group: DG00816
Product (DG00816): D01383<JP/US>
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Synthesis opioid
Phenylpiperidine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa05032  Morphine addiction
Interaction
Structure map
map07028  Antipsychotics
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AB Phenylpiperidine derivatives
     N02AB02 Pethidine
      D08343  Pethidine (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00816  Pethidine
     D08343  Pethidine
 Analgesic
  DG01984  Opioid analgesics
   DG00816  Pethidine
    D08343  Pethidine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D08343  Pethidine (INN)
Narcotics and psychotropics in Japan [br08308.html]
 Narcotics by Control Act Article 2 Table 1 (74 substances)
  D08343
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00816  Pethidine
 Analgesic
  DG01984  Opioid analgesics
   DG00816  Pethidine
Other DBs
CAS: 57-42-1
PubChem: 96025030
ChEBI: 6754
LigandBox: D08343
NIKKAJI: J4.578K
LinkDB
KCF data

ATOM        18
            1   C8x C    25.1300  -16.0300
            2   C8y C    25.1300  -17.4300
            3   C8x C    26.3200  -18.1300
            4   C8x C    27.5100  -17.4300
            5   C8x C    27.5100  -16.0300
            6   C8x C    26.3200  -15.3300
            7   C1z C    23.8700  -18.1300
            8   C1x C    22.6800  -17.5000
            9   C1x C    21.4900  -18.2000
            10  N1y N    21.4900  -19.6000
            11  C1x C    22.6800  -20.2300
            12  C1x C    23.8700  -19.5300
            13  C1a C    20.2300  -20.3000
            14  C7a C    24.5700  -19.3900
            15  O7a O    26.0400  -19.3900
            16  O6a O    23.8700  -20.5800
            17  C1b C    26.6700  -20.5800
            18  C1a C    28.1400  -20.5800
BOND        19
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     2   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13    7  12 1
            14   10  13 1
            15    7  14 1
            16   14  15 1
            17   14  16 2
            18   15  17 1
            19   17  18 1

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KEGG   DRUG: Meperidine hydrochloride
Entry
D01383                      Drug                                   
Name
Meperidine hydrochloride (USP);
Pethidine hydrochloride (JP18);
Demerol (TN)
Product
DEMEROL (Hospira), DEMEROL (Validus Pharmaceuticals LLC)
  Generic
MEPERIDINE HYDROCHLORIDE (EPIC PHARMA), MEPERIDINE HYDROCHLORIDE (Genus Lifesciences), MEPERIDINE HYDROCHLORIDE (Hikma Pharmaceuticals USA), MEPERIDINE HYDROCHLORIDE (Hikma Pharmaceuticals USA)
Formula
C15H21NO2. HCl
Exact mass
283.1339
Mol weight
283.79
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Remark
Therapeutic category: 8211
ATC code: N02AB02
Chemical structure group: DG00816
Product (DG00816): D01383<JP/US>
Product (mixture): D03855<JP>
Efficacy
Analgesic (narcotic), Antispasmodic, Opioid receptor agonist
Comment
Phenylpiperidine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa05032  Morphine addiction
Interaction
Structure map
map07028  Antipsychotics
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AB Phenylpiperidine derivatives
     N02AB02 Pethidine
      D01383  Meperidine hydrochloride (USP) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Opioid Analgesics, Short-acting
   Meperidine
    D01383  Meperidine hydrochloride (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 8  Narcotics
  82  Non-alkaloidal narcotics
   821  Synthetic narcotics
    8211  Phenylpiperazines
     D01383  Meperidine hydrochloride (USP); Pethidine hydrochloride (JP18)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00816  Pethidine
     D01383  Meperidine hydrochloride
 Analgesic
  DG01984  Opioid analgesics
   DG00816  Pethidine
    D01383  Meperidine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D01383  Meperidine hydrochloride (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01383  Pethidine hydrochloride
  D01383  Pethidine hydrochloride for injection
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00816  Pethidine
 Analgesic
  DG01984  Opioid analgesics
   DG00816  Pethidine
Other DBs
CAS: 50-13-5
PubChem: 7848446
ChEBI: 31984
LigandBox: D01383
NIKKAJI: J252.879G
LinkDB
KCF data

ATOM        19
            1   X   Cl   28.2452  -17.0804
            2   C8x C    21.1400  -14.4900
            3   C8y C    21.1400  -15.8900
            4   C8x C    22.3524  -16.5900
            5   C8x C    23.5649  -15.8900
            6   C8x C    23.5649  -14.4900
            7   C8x C    22.3524  -13.7900
            8   C1z C    19.9276  -16.5900
            9   C1x C    18.7321  -15.8996
            10  C1x C    17.5196  -16.5995
            11  N1y N    17.5194  -17.9995
            12  C1x C    18.7149  -18.6899
            13  C1x C    19.9274  -17.9900
            14  C1a C    16.2966  -18.7054
            15  C7a C    20.6276  -17.8024
            16  O7a O    22.0498  -17.8028
            17  O6a O    19.9429  -18.9883
            18  C1b C    22.7397  -18.9983
            19  C1a C    24.1497  -18.9988
BOND        19
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     3   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13    8  13 1
            14   11  14 1
            15    8  15 1
            16   15  16 1
            17   15  17 2
            18   16  18 1
            19   18  19 1

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