| Entry |
|
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| Name |
Promethazine maleate;
Romergan (TN) |
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| Formula |
C17H20N2S. C4H4O4
|
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| Exact mass |
400.1457
|
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| Mol weight |
400.4913
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
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| Remark |
| Product (DG00385): | D00480<JP/US> D03290<JP> D08768<JP> |
|
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| Efficacy |
Antiallergic, H1 receptor antagonist |
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| Comment |
Phenothiazine derivative
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
|
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
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| Interaction |
|
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| Structure map |
| map07029 | Antipsychotics - phenothiazines |
| map07212 | Histamine H1 receptor antagonists |
| map07213 | Dopamine receptor agonists/antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04AA Antihistamines for topical use
D04AA10 Promethazine
D08432 Promethazine maleate
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AD Phenothiazine derivatives
R06AD02 Promethazine
D08432 Promethazine maleate
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00385 Promethazine
D08432 Promethazine maleate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00385 Promethazine
D08432 Promethazine maleate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D08432 Promethazine maleate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08432
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00385 Promethazine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00385 Promethazine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 28
1 N1y N 19.2500 -18.6200
2 C8y C 20.5100 -19.3200
3 C8y C 18.0600 -19.3200
4 C1b C 19.2500 -17.2200
5 C8y C 20.5100 -20.7200
6 C8x C 21.7000 -18.6200
7 C8y C 18.0600 -20.7200
8 C8x C 16.8700 -18.6200
9 C1c C 20.4400 -16.5200
10 S2x S 19.2500 -21.4200
11 C8x C 21.7000 -21.4200
12 C8x C 22.8900 -19.3200
13 C8x C 16.8700 -21.4200
14 C8x C 15.6100 -19.3200
15 N1c N 20.4400 -15.1900
16 C1a C 21.6300 -17.2200
17 C8x C 22.8900 -20.7200
18 C8x C 15.6100 -20.7200
19 C1a C 19.1100 -14.4200
20 C1a C 21.5600 -14.4200
21 C6a C 28.2775 -18.1919
22 O6a O 28.9624 -19.4129
23 O6a O 30.3623 -19.4304
24 C6a C 31.0773 -18.2268
25 C2b C 30.3925 -17.0057
26 C2b C 28.9926 -16.9883
27 O6a O 32.4793 -18.1743
28 O6a O 26.8802 -18.1745
BOND 29
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 5 10 1
10 5 11 1
11 6 12 2
12 7 13 1
13 8 14 2
14 9 15 1
15 9 16 1
16 11 17 2
17 13 18 2
18 15 19 1
19 15 20 1
20 7 10 1
21 12 17 1
22 14 18 1
23 21 22 2
24 23 24 1
25 24 25 1
26 25 26 2
27 21 26 1
28 24 27 2
29 21 28 1
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