| Entry |
|
|---|
| Name |
Unoprostone (INN);
Rescula (TN) |
|---|
| Formula |
C22H38O5
|
|---|
| Exact mass |
382.2719
|
|---|
| Mol weight |
382.53
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Hormonal agent
DG01961 Prostaglandin derivative
DG01960 Prostaglandin F derivative
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
|
|---|
| Remark |
| Product (DG01139): | D01452<JP> |
|
|---|
| Efficacy |
Antiglaucoma, Prostaglandin F receptor agonist |
|---|
| Comment |
Prostaglandin derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07228 | Eicosanoid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01EE Prostaglandin analogues
S01EE02 Unoprostone
D08661 Unoprostone (INN)
Drug groups [BR:br08330]
Hormonal agent
DG01961 Prostaglandin derivative
DG01960 Prostaglandin F derivative
DG01139 Unoprostone
D08661 Unoprostone
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01139 Unoprostone
D08661 Unoprostone
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Prostaglandin
PTGFR
D08661 Unoprostone (INN)
Drug groups [BR:br08330]
Hormonal agent
DG01961 Prostaglandin derivative
DG01960 Prostaglandin F derivative
DG01139 Unoprostone
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01139 Unoprostone
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 27
1 C1y C 18.9311 -21.5876
2 C1y C 18.9311 -22.9898
3 C1y C 17.6691 -21.1669
4 C1b C 20.3335 -20.1151
5 C1y C 17.6691 -23.4106
6 C1b C 20.1231 -23.9715
7 C1x C 16.8277 -22.2887
8 O1a O 17.1783 -19.8347
9 C2b C 21.5254 -20.7462
10 O1a O 17.2484 -24.7427
11 C1b C 21.3150 -23.3404
12 C2b C 22.8576 -20.7462
13 C5a C 22.5070 -23.9715
14 C1b C 24.0495 -20.1151
15 C1b C 23.6989 -23.3404
16 O5a O 22.5070 -25.3737
17 C1b C 25.2415 -20.7462
18 C1b C 24.8909 -23.9715
19 C1b C 26.4334 -20.0450
20 C1b C 26.0828 -23.3404
21 C6a C 27.5553 -20.7462
22 C1b C 27.2047 -23.9715
23 O6a O 28.8173 -20.0450
24 O6a O 27.5554 -22.1485
25 C1b C 28.3966 -23.3404
26 C1b C 29.5886 -24.0416
27 C1a C 30.8506 -23.3404
BOND 27
1 15 18 1
2 17 19 1
3 18 20 1
4 19 21 1
5 20 22 1
6 21 23 1
7 21 24 2
8 22 25 1
9 5 7 1
10 1 2 1
11 1 3 1
12 1 4 1 #Down
13 2 5 1
14 2 6 1 #Up
15 3 7 1
16 3 8 1 #Down
17 4 9 1
18 5 10 1 #Down
19 6 11 1
20 9 12 2
21 11 13 1
22 12 14 1
23 13 15 1
24 13 16 2
25 25 26 1
26 14 17 1
27 26 27 1
|
|---|
