KEGG   DRUG: AlbiglutideHelp
Entry
D08843                      Drug                                   

Name
Albiglutide (USAN);
Albiglutide (genetical recombination) (JAN);
Tanzeum (TN)
Product
Formula
C3232H5032N864O979S41
Exact mass
72923.9078
Mol weight
72970.4029
Sequence
HGEGTFTSDV SSYLEGQAAK EFIAWLVKGR HGEGTFTSDV SSYLEGQAAK EFIAWLVKGR
DAHKSEVAHR FKDLGEENFK ALVLIAFAQY LQQCPFEDHV KLVNEVTEFA KTCVADESAE
NCDKSLHTLF GDKLCTVATL RETYGEMADC CAKQEPERNE CFLQHKDDNP NLPRLVRPEV
DVMCTAFHDN EETFLKKYLY EIARRHPYFY APELLFFAKR YKAAFTECCQ AADKAACLLP
KLDELRDEGK ASSAKQRLKC ASLQKFGERA FKAWAVARLS QRFPKAEFAE VSKLVTDLTK
VHTECCHGDL LECADDRADL AKYICENQDS ISSKLKECCE KPLLEKSHCI AEVENDEMPA
DLPSLAADFV ESKDVCKNYA EAKDVFLGMF LYEYARRHPD YSVVLLLRLA KTYETTLEKC
CAAADPHECY AKVFDEFKPL VEEPQNLIKQ NCELFEQLGE YKFQNALLVR YTKKVPQVST
PTLVEVSRNL GKVGSKCCKH PEAKRMPCAE DYLSVVLNQL CVLHEKTPVS DRVTKCCTES
LVNRRPCFSA LEVDETYVPK EFNAETFTFH ADICTLSEKE RQIKKQTALV ELVKHKPKAT
KEQLKAVMDD FAAFVEKCCK ADDKETCFAE EGKKLVAASQ AALGL
(Disulfide bridge:113-122, 135-151, 150-161, 184-229, 228-237, 260-306, 305-313, 325-339, 338-349, 376-421, 420-429-, 452-498, 497-508, 521-537, 536-547, 574-619, 618-627)
  Type
Peptide
Class
Antidiabetic agent
 DG01493  GLP-1 receptor agonist
 DG02044  Hypoglycemics
  DG01493  GLP-1 receptor agonist
Remark
ATC code: A10BJ04
Product: D08843<US>
Efficacy
Antidiabetic, Glucagon-like peptide 1 (GLP-1) receptor agonist
  Disease
Type 2 diabetes mellitus [DS:H00409]
Comment
GLP-1 [HSA:2641] [KO:K05259] analog - Albumin conjugate
Target
GLP1R [HSA:2740] [KO:K04581]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04911  Insulin secretion
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BJ Glucagon-like peptide-1 receptor (GLP-1) analogues
     A10BJ04 Albiglutide
      D08843  Albiglutide (USAN) <US>
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Albiglutide
    D08843  Albiglutide (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Secretin receptor family
   Glucagon
    GLP1R
     D08843  Albiglutide (USAN) <US>
Drug classes of therapeutic agents [br08360.html]
 Antidiabetic agents
  D08843
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D08843
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D08843
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D08843
BRITE hierarchy
Other DBs
CAS: 782500-75-8
PubChem: 96025526
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