KEGG   DRUG: Romiplostim
Entry
D08990                      Drug                                   
Name
Romiplostim (USAN/INN);
Romiplostim (genetical recombination) (JAN);
Nplate (TN);
Romiplate (TN)
Product
Formula
C1317H2043N361O395S9
Exact mass
29523.8362
Mol weight
29542.08
Remark
Therapeutic category: 3999
ATC code: B02BX04
Product: D08990<JP/US>
Efficacy
Antithrombocytopenia, Thrombopoietin receptor agonist
  Disease
Chronic immune thrombocytopenia [DS:H01240]
Comment
Fusion protein (Thrombopoietin-binding peptide fused to Fc of human IgG1)
Treatment of immune thrombocytopenic purpura (ITP)
Target
MPL (TPOR, CD110) [HSA:4352] [KO:K05082]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BX Other systemic hemostatics
     B02BX04 Romiplostim
      D08990  Romiplostim (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Blood Products and Modifiers, Other
   Blood Products and Modifiers, Micellaneous
    Romiplostim
     D08990  Romiplostim (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D08990  Romiplostim (USAN/INN); Romiplostim (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   CSF and other factor receptors
    MPL (TPOR, CD110)
     D08990  Romiplostim (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D08990
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D08990
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D08990
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D08990
Other DBs
CAS: 267639-76-9
PubChem: 96025673
LinkDB

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