KEGG   DRUG: LosmapimodHelp
Entry
D09639                      Drug                                   

Name
Losmapimod (USAN/INN)
Formula
C22H26FN3O2
Exact mass
383.2009
Mol weight
383.4591
Structure
Mol fileKCF fileDB search
Efficacy
Anti-inflammatory, Mitogen-activated protein kinase inhibitor
Comment
Treatment of COPD, major depressive disorder, acute coronary syndrome, neuropathic pain
Target
P38 [HSA:1432 5600 5603 6300] [KO:K04441]
  Pathway
hsa04370  VEGF signaling pathway
hsa04620  Toll-like receptor signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine kinases
   MAPK family
    P38
     D09639  Losmapimod (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 585543-15-3
PubChem: 124490379
ChEMBL: CHEMBL1088752
LigandBox: D09639
LinkDB All DBs
KCF data Show

ATOM        28
            1   N5x N    15.6800  -19.3200
            2   C8y C    15.6800  -20.7200
            3   C8x C    16.8700  -21.4200
            4   C8x C    18.1300  -20.7200
            5   C8y C    18.1300  -19.3200
            6   C8x C    16.8700  -18.6200
            7   C8y C    14.4900  -21.4200
            8   C8x C    13.3000  -20.7200
            9   C8y C    12.0400  -21.4200
            10  C8x C    12.0400  -22.8200
            11  C8y C    13.2300  -23.5200
            12  C8y C    14.4900  -22.8200
            13  C5a C    19.3200  -18.6200
            14  N1b N    20.5100  -19.3200
            15  C1b C    21.7000  -18.6200
            16  C1d C    22.8900  -19.3200
            17  C1a C    24.0800  -18.6200
            18  C1a C    22.8900  -20.7200
            19  C1a C    24.1500  -20.0200
            20  O5a O    19.3200  -17.2200
            21  C1a C    15.6800  -23.5200
            22  X   F    13.2300  -24.9200
            23  C5a C    10.8500  -20.7200
            24  N1b N     9.6600  -21.4200
            25  C1y C     8.4700  -20.7200
            26  O5a O    10.8500  -19.3200
            27  C1x C     7.7700  -19.5076
            28  C1x C     7.0700  -20.7200
BOND        30
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     2   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13    7  12 1
            14    5  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   16  18 1
            20   16  19 1
            21   13  20 2
            22   12  21 1
            23   11  22 1
            24    9  23 1
            25   23  24 1
            26   24  25 1
            27   23  26 2
            28   25  27 1
            29   25  28 1
            30   27  28 1

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