| Entry |
|
|---|
| Name |
Losmapimod (USAN/INN) |
|---|
| Formula |
C22H26FN3O2
|
|---|
| Exact mass |
383.2009
|
|---|
| Mol weight |
383.46
|
|---|
| Structure |
|
|---|
| Efficacy |
Anti-inflammatory, Mitogen-activated protein kinase inhibitor |
|---|
| Comment |
Treatment of COPD, major depressive disorder, acute coronary syndrome, neuropathic pain
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04620 | Toll-like receptor signaling pathway |
|
|---|
| Brite |
Target-based classification of drugs [BR:br08310]
Protein kinases
Serine/threonine kinases
CMGC group
P38
D09639 Losmapimod (USAN/INN)
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 28
1 N5x N 15.6800 -19.3200
2 C8y C 15.6800 -20.7200
3 C8x C 16.8700 -21.4200
4 C8x C 18.1300 -20.7200
5 C8y C 18.1300 -19.3200
6 C8x C 16.8700 -18.6200
7 C8y C 14.4900 -21.4200
8 C8x C 13.3000 -20.7200
9 C8y C 12.0400 -21.4200
10 C8x C 12.0400 -22.8200
11 C8y C 13.2300 -23.5200
12 C8y C 14.4900 -22.8200
13 C5a C 19.3200 -18.6200
14 N1b N 20.5100 -19.3200
15 C1b C 21.7000 -18.6200
16 C1d C 22.8900 -19.3200
17 C1a C 24.0800 -18.6200
18 C1a C 22.8900 -20.7200
19 C1a C 24.1500 -20.0200
20 O5a O 19.3200 -17.2200
21 C1a C 15.6800 -23.5200
22 X F 13.2300 -24.9200
23 C5a C 10.8500 -20.7200
24 N1b N 9.6600 -21.4200
25 C1y C 8.4700 -20.7200
26 O5a O 10.8500 -19.3200
27 C1x C 7.7700 -19.5076
28 C1x C 7.0700 -20.7200
BOND 30
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 2 7 1
8 7 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 11 12 2
13 7 12 1
14 5 13 1
15 13 14 1
16 14 15 1
17 15 16 1
18 16 17 1
19 16 18 1
20 16 19 1
21 13 20 2
22 12 21 1
23 11 22 1
24 9 23 1
25 23 24 1
26 24 25 1
27 23 26 2
28 25 27 1
29 25 28 1
30 27 28 1
|
|---|
