| Entry |
|
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| Name |
Pixantrone dimaleate (USAN);
Pixuvri (TN) |
|---|
| Formula |
C17H19N5O2. (C4H4O4)2
|
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| Exact mass |
557.1758
|
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| Mol weight |
557.5094
|
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| Structure |
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| Class |
Antineoplastic
DG01682 Anthracycline antineoplastic
DG01727 Anthraquinone antineoplastic
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
|
|---|
| Remark |
|
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| Efficacy |
Antineoplastic, Topoisomerase II inhibitor |
|---|
| Comment |
anthraquinone derivative
Treatment of Non-Hodgkin's Lymphoma (NHL)
|
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| Target |
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
L01DB Anthracyclines and related substances
L01DB11 Pixantrone
D09654 Pixantrone dimaleate (USAN)
Drug groups [BR:br08330]
Antineoplastic
DG01682 Anthracycline antineoplastic
DG00704 Pixantrone
D09654 Pixantrone dimaleate
DG01727 Anthraquinone antineoplastic
DG00704 Pixantrone
D09654 Pixantrone dimaleate
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
DG00704 Pixantrone
D09654 Pixantrone dimaleate
Target-based classification of drugs [BR:br08310]
Enzymes
Isomerases (EC5)
DNA topoisomerase
TOP2
D09654 Pixantrone dimaleate (USAN)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D09654
Drug groups [BR:br08330]
Antineoplastic
DG01682 Anthracycline antineoplastic
DG00704 Pixantrone
DG01727 Anthraquinone antineoplastic
DG00704 Pixantrone
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
DG00704 Pixantrone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 40
1 N5x N 16.1893 -25.1785
2 C8x C 16.1893 -26.5695
3 C8x C 17.3717 -27.2650
4 C8y C 18.6236 -26.5695
5 C8y C 18.6236 -25.1785
6 C8x C 17.3717 -24.4830
7 C5x C 19.8060 -27.2650
8 C8y C 20.9884 -26.5695
9 C8y C 20.9884 -25.1785
10 C5x C 19.8060 -24.4830
11 C8y C 22.2403 -27.2650
12 C8x C 23.4227 -26.5695
13 C8x C 23.4227 -25.1785
14 C8y C 22.2403 -24.4830
15 O5x O 19.8060 -23.0920
16 O5x O 19.8060 -28.6561
17 N1b N 22.2403 -23.0920
18 C1b C 23.4227 -22.3964
19 N1b N 22.2403 -28.6561
20 C1b C 23.4227 -29.4211
21 C1b C 24.6746 -28.7256
22 N1a N 25.8570 -29.3516
23 C1b C 24.6746 -23.0920
24 N1a N 25.8570 -22.3964
25 C2b C 30.5959 -24.6916
26 C2b C 28.9266 -24.6916
27 C6a C 28.2311 -25.8963
28 O6a O 28.9266 -27.1010
29 O6a O 30.5959 -27.1010
30 C6a C 31.2914 -25.8963
31 O6a O 26.8403 -25.8963
32 O6a O 32.6822 -25.8963
33 C2b C 30.5959 -24.6916
34 C2b C 28.9266 -24.6916
35 C6a C 28.2311 -25.8963
36 O6a O 28.9266 -27.1010
37 O6a O 26.8403 -25.8963
38 C6a C 31.2914 -25.8963
39 O6a O 30.5959 -27.1010
40 O6a O 32.6822 -25.8963
BOND 40
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 8 11 2
13 11 12 1
14 12 13 2
15 13 14 1
16 9 14 2
17 10 15 2
18 7 16 2
19 14 17 1
20 17 18 1
21 11 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 18 23 1
26 23 24 1
27 25 26 2
28 26 27 1
29 27 28 2
30 29 30 1
31 25 30 1
32 27 31 1
33 30 32 2
34 33 34 2
35 34 35 1
36 35 36 2
37 39 38 1
38 33 38 1
39 35 37 1
40 38 40 2
BRACKET 1 25.6900 -27.7900 25.6900 -23.9400
1 33.4600 -23.9400 33.4600 -27.7900
1 2
ORIGINAL 1 25 26 27 28 31 30 29 32
REPEAT 1 33 34 35 36 37 38 39 40
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