KEGG   DRUG: AtaciceptHelp
Entry
D09704                      Drug                                   

Name
Atacicept (USAN/INN)
Formula
C3104H4788N856O950S44
Exact mass
70662.0376
Mol weight
70707.2547
Sequence
AMRSCPEEQY WDPLLGTCMS CKTICNHQSQ RTCAAFCRSL SCRKEQGKFY DHLLRDCISC
ASICGQHPKQ CAYFCENKLR SEPKSSDKTH TCPPCPAPEA EGAPSVFLFP PKPKDTLMIS
RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL
NGKEYKCKVS NKALPSSIEK TISKAKGQPR EPQVYTLPPS RDELTKNQVS LTCLVKGFYP
SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN
HYTQKSLSLS PGK
(Disulfide bridge: 5-18; 21-33; 25-37; 42-57; 60-71; 64-75; 127-187; 233-291, Dimer: 92; 95)
  Type
Peptide
Efficacy
Immunosuppressant
Comment
fusion protein (TACI [HSA:23495] [KO:K05150] - Ig)
Treatment of autoimmune disease
Target
TNFSF13 (APRIL) [HSA:8741] [KO:K05475]
TNFSF13B (BAFF, CD257) [HSA:10673] [KO:K05476]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa05323  Rheumatoid arthritis
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    TNFSF13 (APRIL)
     D09704  Atacicept (USAN/INN)
    TNFSF13B (BAFF, CD257)
     D09704  Atacicept (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 845264-92-8
PubChem: 124490444
LinkDB All DBs

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