| Entry |
|
|---|
| Name |
Edoxaban (USAN/INN) |
|---|
| Formula |
C24H30ClN7O4S
|
|---|
| Exact mass |
547.1769
|
|---|
| Mol weight |
548.0575
|
|---|
| Structure |
|
|---|
| Class |
Blood modifier agent
DG01950 Antithrombotic agent
DG01662 Factor Xa inhibitor
Transporter substrate
DG01665 ABCB1 substrate
|
|---|
| Remark |
| Product (DG01398): | D09546<JP/US> |
|
|---|
| Efficacy |
Antithrombotic, Factor Xa inhibitor |
|---|
| Target |
|
|---|
| Pathway |
| hsa04610 | Complement and coagulation cascades |
|
|---|
| Metabolism |
Transporter: ABCB1 [HSA: 5243]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
B BLOOD AND BLOOD FORMING ORGANS
B01 ANTITHROMBOTIC AGENTS
B01A ANTITHROMBOTIC AGENTS
B01AF Direct factor Xa inhibitors
B01AF03 Edoxaban
D09710 Edoxaban (USAN/INN)
Drug groups [BR:br08330]
Blood modifier agent
DG01950 Antithrombotic agent
DG01662 Factor Xa inhibitor
DG01398 Edoxaban
D09710 Edoxaban
Transporter substrate
DG01665 ABCB1 substrate
DG01398 Edoxaban
D09710 Edoxaban
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Serine peptidases
F10
D09710 Edoxaban (USAN/INN)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D09710
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D09710
Drug groups [BR:br08330]
Blood modifier agent
DG01950 Antithrombotic agent
DG01662 Factor Xa inhibitor
DG01398 Edoxaban
Transporter substrate
DG01665 ABCB1 substrate
DG01398 Edoxaban
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 37
1 C1x C 19.6700 -24.9200
2 C1y C 19.6700 -26.3200
3 C1y C 20.9300 -27.0200
4 C1x C 22.1200 -26.3200
5 C1x C 22.1200 -24.9200
6 C1y C 20.9300 -24.2200
7 C5a C 20.9300 -22.8200
8 O5a O 19.6700 -22.1200
9 N1c N 22.1200 -22.1200
10 C1a C 23.3100 -22.8200
11 C1a C 22.1200 -20.7200
12 N1b N 20.9300 -28.4900
13 C5a C 22.1200 -29.1200
14 C5a C 23.3100 -28.4900
15 O5a O 22.1200 -30.5900
16 N1b N 24.5000 -29.1200
17 O5a O 23.3100 -27.0200
18 C8y C 25.6900 -28.4900
19 N5x N 26.8800 -29.1200
20 C8x C 28.0700 -28.4200
21 C8y C 28.0700 -27.0200
22 C8x C 26.8800 -26.3200
23 C8x C 25.6900 -27.0900
24 X Cl 29.3300 -26.3200
25 N1b N 18.4800 -27.0200
26 C5a C 17.2900 -26.3900
27 C8y C 16.1000 -27.0200
28 O5a O 17.2900 -24.9200
29 N5x N 14.8400 -26.4600
30 C8y C 13.8600 -27.5100
31 C8y C 14.5600 -28.7000
32 S2x S 15.9600 -28.4200
33 C1x C 12.4600 -27.5100
34 C1x C 11.7600 -28.7000
35 N1y N 12.4600 -29.8900
36 C1x C 13.8600 -29.8900
37 C1a C 11.7600 -31.1500
BOND 40
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 1
7 6 7 1 #Up
8 7 8 2
9 7 9 1
10 9 10 1
11 9 11 1
12 3 12 1 #Down
13 12 13 1
14 13 14 1
15 13 15 2
16 14 16 1
17 14 17 2
18 16 18 1
19 18 19 2
20 19 20 1
21 20 21 2
22 21 22 1
23 22 23 2
24 18 23 1
25 21 24 1
26 2 25 1 #Down
27 25 26 1
28 26 27 1
29 26 28 2
30 27 29 2
31 29 30 1
32 30 31 2
33 31 32 1
34 27 32 1
35 30 33 1
36 33 34 1
37 34 35 1
38 35 36 1
39 31 36 1
40 35 37 1
|
|---|
