| Entry |
|
|---|
| Name |
Edoxaban (USAN/INN) |
|---|
| Formula |
C24H30ClN7O4S
|
|---|
| Exact mass |
547.1769
|
|---|
| Mol weight |
548.06
|
|---|
| Structure |
|
|---|
| Class |
Blood modifier agent
DG01950 Antithrombotic agent
DG01662 Factor Xa inhibitor
DG03320 Direct oral anticoagulant (DOAC)
Transporter substrate
DG01665 ABCB1 substrate
|
|---|
| Remark |
| Product (DG01398): | D09546<JP/US> |
|
|---|
| Efficacy |
Antithrombotic, Factor Xa inhibitor |
|---|
| Target |
|
|---|
| Pathway |
| hsa04610 | Complement and coagulation cascades |
|
|---|
| Metabolism |
Transporter: ABCB1 [HSA: 5243]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
B BLOOD AND BLOOD FORMING ORGANS
B01 ANTITHROMBOTIC AGENTS
B01A ANTITHROMBOTIC AGENTS
B01AF Direct factor Xa inhibitors
B01AF03 Edoxaban
D09710 Edoxaban (USAN/INN)
Drug groups [BR:br08330]
Blood modifier agent
DG01950 Antithrombotic agent
DG01662 Factor Xa inhibitor
DG01398 Edoxaban
D09710 Edoxaban
DG03320 Direct oral anticoagulant (DOAC)
DG01398 Edoxaban
D09710 Edoxaban
Transporter substrate
DG01665 ABCB1 substrate
DG01398 Edoxaban
D09710 Edoxaban
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Serine peptidases
F10
D09710 Edoxaban (USAN/INN)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D09710
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D09710
Drug groups [BR:br08330]
Blood modifier agent
DG01950 Antithrombotic agent
DG01662 Factor Xa inhibitor
DG01398 Edoxaban
DG03320 Direct oral anticoagulant (DOAC)
DG01398 Edoxaban
Transporter substrate
DG01665 ABCB1 substrate
DG01398 Edoxaban
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 37
1 C1x C 19.6700 -24.9200
2 C1y C 19.6700 -26.3200
3 C1y C 20.9300 -27.0200
4 C1x C 22.1200 -26.3200
5 C1x C 22.1200 -24.9200
6 C1y C 20.9300 -24.2200
7 C5a C 20.9300 -22.8200
8 O5a O 19.6700 -22.1200
9 N1c N 22.1200 -22.1200
10 C1a C 23.3100 -22.8200
11 C1a C 22.1200 -20.7200
12 N1b N 20.9300 -28.4900
13 C5a C 22.1200 -29.1200
14 C5a C 23.3100 -28.4900
15 O5a O 22.1200 -30.5900
16 N1b N 24.5000 -29.1200
17 O5a O 23.3100 -27.0200
18 C8y C 25.6900 -28.4900
19 N5x N 26.8800 -29.1200
20 C8x C 28.0700 -28.4200
21 C8y C 28.0700 -27.0200
22 C8x C 26.8800 -26.3200
23 C8x C 25.6900 -27.0900
24 X Cl 29.3300 -26.3200
25 N1b N 18.4800 -27.0200
26 C5a C 17.2900 -26.3900
27 C8y C 16.1000 -27.0200
28 O5a O 17.2900 -24.9200
29 N5x N 14.8400 -26.4600
30 C8y C 13.8600 -27.5100
31 C8y C 14.5600 -28.7000
32 S2x S 15.9600 -28.4200
33 C1x C 12.4600 -27.5100
34 C1x C 11.7600 -28.7000
35 N1y N 12.4600 -29.8900
36 C1x C 13.8600 -29.8900
37 C1a C 11.7600 -31.1500
BOND 40
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 1
7 6 7 1 #Up
8 7 8 2
9 7 9 1
10 9 10 1
11 9 11 1
12 3 12 1 #Down
13 12 13 1
14 13 14 1
15 13 15 2
16 14 16 1
17 14 17 2
18 16 18 1
19 18 19 2
20 19 20 1
21 20 21 2
22 21 22 1
23 22 23 2
24 18 23 1
25 21 24 1
26 2 25 1 #Down
27 25 26 1
28 26 27 1
29 26 28 2
30 27 29 2
31 29 30 1
32 30 31 2
33 31 32 1
34 27 32 1
35 30 33 1
36 33 34 1
37 34 35 1
38 35 36 1
39 31 36 1
40 35 37 1
|
|---|
