KEGG   DRUG: DalotuzumabHelp
Entry
D09746                      Drug                                   

Name
Dalotuzumab (USAN)
Sequence
(A chain) QVQLQESGPG LVKPSETLSL TCTVSGYSIT GGYLWNWIRQ PPGKGLEWIG
YISYDGTNNY KPSLKDRVTI SRDTSKNQFS LKLSSVTAAD TAVYYCARYG RVFFDYWGQG
TLVTVSSAST KGPSVFPLAP SSKSTSGGTA ALGCLVKDYF PEPVTVSWNS GALTSGVHTF
PAVLQSSGLY SLSSVVTVPS SSLGTQTYIC NVNHKPSNTK VDKRVEPKSC DKTHTCPPCP
APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK
PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT
LPPSREEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL
TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGK
(disulfide bridge: 22-96; 144-200; 261-321; 367-425, dimer: 226-226'; 229-229')
(B chain) DIVMTQSPLS LPVTPGEPAS ISCRSSQSIV HSNGNTYLQW YLQKPGQSPQ
LLIYKVSNRL YGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCFQGSHVP WTFGQGTKVE
IKRTVAAPSV FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE
QDSKDSTYSL SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(disulfide bridge: 23-93; 139-199)
(dimer: A220-B219; A'220-B'219)
  Type
Peptide
Efficacy
Antineoplastic, Anti-insulin-like growth factor (IGF) 1 receptor antibody
Comment
Monoclonal antibody
Target
IGF1R (CD221) [HSA:3480] [KO:K05087]
  Pathway
hsa04510  Focal adhesion
hsa04520  Adherens junction
hsa05200  Pathways in cancer
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   INSR family
    IGF1R (CD221)
     D09746  Dalotuzumab (USAN)
BRITE hierarchy
Other DBs
CAS: 1005389-60-5
PubChem: 124490486
LinkDB All DBs

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