KEGG   DRUG: DulaglutideHelp
Entry
D09889                      Drug                                   

Name
Dulaglutide (USAN/INN);
Dulaglutide (genetical recombination) (JAN);
Trulicity (TN)
Product
Formula
C2646H4044N704O836S18
Exact mass
59633.0544
Mol weight
59669.8068
Sequence
HGEGTFTSDV  SSYLEEQAAK  EFIAWLVKGG  GGGGGSGGGG  SGGGGSAESK
50 YGPPCPPCPA  PEAAGGPSVF  LFPPKPKDTL  MISRTPEVTC  VVVDVSQEDP
100 EVQFNWYVDG  VEVHNAKTKP  REEQFNSTYR  VVSVLTVLHQ  DWLNGKEYKC
150 KVSNKGLPSS  IEKTISKAKG  QPREPQVYTL  PPSQEEMTKN  QVSLTCLVKG
200 FYPSDIAVEW  ESNGQPENNY  KTTPPVLDSD  GSFFLYSRLT  VDKSRWQEGN
250 VFSCSVMHEA  LHNHYTQKSL  SLSLG
(Disulfide bridge: 90-150; 196-254. Dimer: 55; 58)
  Type
Peptide
Class
Antidiabetic agent
 DG01493  GLP-1 receptor agonist
 DG02044  Hypoglycemics
  DG01493  GLP-1 receptor agonist
Remark
Therapeutic category: 2499
ATC code: A10BJ05
Product: D09889<JP/US>
Efficacy
Antidiabetic, Glucagon-like peptide 1 (GLP-1) receptor agonist
  Disease
Type 2 diabetes mellitus [DS:H00409]
Comment
Fc fusion protein of GLP-1 [HSA:2641] [KO:K05259] analog
Treatment of type II diabetes
Target
GLP1R [HSA:2740] [KO:K04581]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04911  Insulin secretion
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BJ Glucagon-like peptide-1 receptor (GLP-1) analogues
     A10BJ05 Dulaglutide
      D09889  Dulaglutide (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Dulaglutide
    D09889  Dulaglutide (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D09889  Dulaglutide (USAN/INN); Dulaglutide (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Secretin receptor family
   Glucagon
    GLP1R
     D09889  Dulaglutide (USAN/INN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Antidiabetic agents
  D09889
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D09889
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09889
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09889
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09889
BRITE hierarchy
Other DBs
CAS: 923950-08-7
PubChem: 124490606
LinkDB All DBs

» Japanese version   » Back

DBGET integrated database retrieval system