KEGG   DRUG: EnavatuzumabHelp
Entry
D09896                      Drug                                   

Name
Enavatuzumab (USAN/INN)
Formula
C6494H10004N1720O2038S48
Exact mass
146227.8643
Mol weight
146318.3388
Sequence
(Heavy chain) EVQLVESGGG LVQPGGSLRL SCAASGFTFS SYWMSWVRQA
PGKGLEWVAE IRLKSDNYAT HYAESVKGRF TISRDDSKNS LYLQMNSLRA EDTAVYYCTG
YYADAMDYWG QGTLVTVSSA STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW
NSGALTSGVH TFPAVLQSSG LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKKVEPK
SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY
VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK
AKGQPREPQV YTLPPSREEM TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL
DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(Disulfide bridge: 22-98; 146-202; 263-323; 369-427, Dimer: 228; 231)
(Light chain) DIQMTQSPSS LSASVGDRVT ITCRASQSVS TSSYSYMHWY
QQKPGKAPKL LIKYASNLES GVPSRFSGSG SGTDFTLTIS SLQPEDFATY YCQHSWEIPY
TFGGGTKVEI KRTVAAPSVF IFPPSDEQLK SGTASVVCLL NNFYPREAKV QWKVDNALQS
GNSQESVTEQ DSKDSTYSLS STLTLSKADY EKHKVYACEV THQGLSSPVT KSFNRGEC
(Disulfide bridge: 23-92; 138-198; H222-L218, Dimer)
  Type
Peptide
Efficacy
Antineoplastic
Comment
Monoclonal antibody
Treatment of solid tumors
Target
TNFRSF12A (TWEAKR, CD266) [HSA:51330] [KO:K05149]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Tumor necrosis factor receptors
    TNFRSF12A (TWEAKR, CD266)
     D09896  Enavatuzumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 1062149-33-0
PubChem: 124490609
LinkDB All DBs

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