KEGG   DRUG: Enokizumab
Entry
D09897                      Drug                                   
Name
Enokizumab (USAN/INN)
Formula
C6496H10000N1704O2038S44
Exact mass
145895.8955
Mol weight
145985.9612
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGSSVKV SCKASGGTFS YYWIEWVRQA PGQGLEWMGE ILPGSGTTNP
NEKFKGRVTI TADESTSTAY MELSSLRSED TAVYYCARAD YYGSDYVKFD YWGQGTLVTV
SSASTKGPSV FPLAPSSKST SGGTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ
SSGLYSLSSV VTVPSSSLGT QTYICNVNHK PSNTKVDKRV EPKSCDKTHT CPPCPAPELL
GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ
YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR
EEMTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS
RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCKASQHVI THVTWYQQKP GKAPKLLIYG TSYSYSGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ FYEYPLTFGG GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H149-H205, H266-H326, H372-H430, H231-H'231, 234-H'234, L23-L88, L134-L194, H225-L214)
  Type
Peptide
Class
Immunological agent
 DG02019  Interleukin inhibitor
Efficacy
Antiasthmatic, Anti-IL-9 antibody
Comment
Monoclonal antibody
Target
IL9 [HSA:3578] [KO:K05432]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
hsa05310  Asthma
Brite
Drug groups [BR:br08330]
 Immunological agent
  DG02019  Interleukin inhibitor
   D09897  Enokizumab
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Interleukins
    IL9
     D09897  Enokizumab (USAN/INN)
Other DBs
CAS: 909875-08-7
PubChem: 124490610
LinkDB

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