KEGG   DRUG: GanitumabHelp
Entry
D09908                      Drug                                   

Name
Ganitumab (USAN/INN)
Formula
C6472H10028N1728O2020S42
Exact mass
145620.3358
Mol weight
145709.9683
Sequence
(Heavy chain) QVQLQESGPG LVKPSGTLSL TCAVSGGSIS SSNWWSWVRQ
PPGKGLEWIG EIYHSGSTNY NPSLKSRVTI SVDKSKNQFS LKLSSVTAAD TAVYYCARWT
GRTDAFDIWG QGTMVTVSSA STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW
NSGALTSGVH TFPAVLQSSG LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKKVEPK
SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY
VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK
AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL
DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(Disulfide bridge: 22-96; 146-202; 263-323; 369-427, Dimer: 228; 231)
(Light chain) DVVMTQSPLS LPVTPGEPAS ISCRSSQSLL HSNGYNYLDW
YLQKPGQSPQ LLIYLGSNRA SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCMQGTHWP
LTFGQGTKVE IKRTVAAPSV FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ
SGNSQESVTE QDSKDSTYSL SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: 23-93; 139-199; H222-L219, Dimer)
  Type
Peptide
Efficacy
Antineoplastic, Insulin-like growth factor 1 receptor antibody
Comment
Monoclonal antibody
Target
IGF1R (CD221) [HSA:3480] [KO:K05087]
  Pathway
hsa04510  Focal adhesion
hsa04520  Adherens junction
hsa05200  Pathways in cancer
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   INSR family
    IGF1R (CD221)
     D09908  Ganitumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 905703-97-1
PubChem: 124490615
LinkDB All DBs

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