KEGG   DRUG: LinsitinibHelp
Entry
D09925                      Drug                                   

Name
Linsitinib (USAN/INN)
Formula
C26H23N5O
Exact mass
421.1903
Mol weight
421.4937
Structure
Mol fileKCF fileDB search
Efficacy
Antineoplastic, Insulin-like growth factor 1 receptor antagonist
Comment
Treatment of solid tumors
Target
IGF1R (CD221) [HSA:3480] [KO:K05087]
  Pathway
hsa04510  Focal adhesion
hsa04520  Adherens junction
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   INSR family
    IGF1R (CD221)
     D09925  Linsitinib (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 867160-71-2
PubChem: 135626662
ChEMBL: CHEMBL1091644
LigandBox: D09925
LinkDB All DBs
KCF data Show

ATOM        32
            1   C8y C    15.0500  -19.9500
            2   C8x C    15.0500  -21.3500
            3   C8x C    16.2624  -22.0500
            4   C8y C    17.4749  -21.3500
            5   C8y C    17.4749  -19.9500
            6   C8x C    16.2624  -19.2500
            7   C8x C    18.6873  -22.0500
            8   C8x C    19.8997  -21.3500
            9   C8y C    19.8997  -19.9500
            10  N5x N    18.6873  -19.2500
            11  C8y C    21.0973  -19.2585
            12  C8x C    22.2856  -19.9445
            13  C8x C    23.4980  -19.2445
            14  C8x C    23.4980  -17.8445
            15  C8x C    22.3097  -17.1585
            16  C8x C    21.0973  -17.8585
            17  C8y C    13.8376  -19.2500
            18  C8y C    13.8376  -17.8500
            19  N4y N    12.5061  -17.4174
            20  C8y C    11.6832  -18.5500
            21  N5x N    12.5061  -19.6826
            22  C8y C    14.8780  -16.9132
            23  N5x N    14.5869  -15.5438
            24  C8x C    13.2554  -15.1112
            25  C8x C    12.2150  -16.0480
            26  C1y C    10.2900  -18.5500
            27  C1x C     9.3001  -17.5601
            28  C1z C     8.3101  -18.5500
            29  C1x C     9.3001  -19.5399
            30  O1a O     7.0977  -17.8500
            31  C1a C     7.0977  -19.2500
            32  N1a N    16.2463  -17.3574
BOND        37
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   11  16 2
            19    1  17 1
            20   17  18 2
            21   18  19 1
            22   19  20 1
            23   20  21 2
            24   17  21 1
            25   18  22 1
            26   22  23 2
            27   23  24 1
            28   24  25 2
            29   19  25 1
            30   26  20 1 #Up
            31   26  27 1
            32   27  28 1
            33   28  29 1
            34   26  29 1
            35   28  30 1 #Up
            36   28  31 1 #Down
            37   22  32 1

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