| Entry |
|
|---|
| Name |
Linsitinib (USAN/INN) |
|---|
| Formula |
C26H23N5O
|
|---|
| Exact mass |
421.1903
|
|---|
| Mol weight |
421.49
|
|---|
| Structure |
|
|---|
| Efficacy |
Antineoplastic, Insulin-like growth factor 1 receptor antagonist |
|---|
| Comment |
Treatment of solid tumors
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Brite |
Target-based classification of drugs [BR:br08310]
Protein kinases
Receptor tyrosine kinases (RTK)
INSR family
IGF1R (CD221)
D09925 Linsitinib (USAN/INN)
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 32
1 C8y C 15.0500 -19.9500
2 C8x C 15.0500 -21.3500
3 C8x C 16.2624 -22.0500
4 C8y C 17.4749 -21.3500
5 C8y C 17.4749 -19.9500
6 C8x C 16.2624 -19.2500
7 C8x C 18.6873 -22.0500
8 C8x C 19.8997 -21.3500
9 C8y C 19.8997 -19.9500
10 N5x N 18.6873 -19.2500
11 C8y C 21.0973 -19.2585
12 C8x C 22.2856 -19.9445
13 C8x C 23.4980 -19.2445
14 C8x C 23.4980 -17.8445
15 C8x C 22.3097 -17.1585
16 C8x C 21.0973 -17.8585
17 C8y C 13.8376 -19.2500
18 C8y C 13.8376 -17.8500
19 N4y N 12.5061 -17.4174
20 C8y C 11.6832 -18.5500
21 N5x N 12.5061 -19.6826
22 C8y C 14.8780 -16.9132
23 N5x N 14.5869 -15.5438
24 C8x C 13.2554 -15.1112
25 C8x C 12.2150 -16.0480
26 C1y C 10.2900 -18.5500
27 C1x C 9.3001 -17.5601
28 C1z C 8.3101 -18.5500
29 C1x C 9.3001 -19.5399
30 O1a O 7.0977 -17.8500
31 C1a C 7.0977 -19.2500
32 N1a N 16.2463 -17.3574
BOND 37
1 1 2 1
2 2 3 2
3 3 4 1
4 4 5 2
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 2
9 8 9 1
10 9 10 2
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 2
15 13 14 1
16 14 15 2
17 15 16 1
18 11 16 2
19 1 17 1
20 17 18 2
21 18 19 1
22 19 20 1
23 20 21 2
24 17 21 1
25 18 22 1
26 22 23 2
27 23 24 1
28 24 25 2
29 19 25 1
30 26 20 1 #Up
31 26 27 1
32 27 28 1
33 28 29 1
34 26 29 1
35 28 30 1 #Up
36 28 31 1 #Down
37 22 32 1
|
|---|
