KEGG   DRUG: Mavrilimumab
Entry
D09930                      Drug                                   
Name
Mavrilimumab (USAN/INN)
Formula
C6706H10438N1762O2104S54
Exact mass
151044.8863
Mol weight
151138.79
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKV SCKVSGYTLT ELSIHWVRQA PGKGLEWMGG FDPEENEIVY
AQRFQGRVTM TEDTSTDTAY MELSSLRSED TAVYYCAIVG SFSPLTLGLW GQGTMVTVSS
ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
GLYSLSSVVT VPSSSLGTKT YTCNVDHKPS NTKVDKRVES KYGPPCPSCP APEFLGGPSV
FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY
RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK
NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG
NVFSCSVMHE ALHNHYTQKS LSLSLGK
(Light chain)
QSVLTQPPSV SGAPGQRVTI SCTGSGSNIG APYDVSWYQQ LPGTAPKLLI YHNNKRPSGV
PDRFSGSKSG TSASLAITGL QAEDEADYYC ATVEAGLSGS VFGGGTKLTV LGQPKAAPSV
TLFPPSSEEL QANKATLVCL ISDFYPGAVT VAWKADSSPV KAGVETTTPS KQSNNKYAAS
SYLSLTPEQW KSHRSYSCQV THEGSTVEKT VAPTECS
(Disulfide bridge: H22-H96, H147-H203, H261-H321, H367-H425, H226-H'226, H229-H'229, L22-L90, L139-L198, H134-L216)
  Type
Peptide
Efficacy
Antirheumatic, Anti-GMCSF receptor antibody
  Type
Monoclonal antibody
Comment
Treatment of rheumatoid arthritis
Target
CSF2RA (GMCSFR, CD116) [HSA:1438] [KO:K05066]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   CSF and other factor receptors
    CSF2RA (GMCSFR, CD116)
     D09930  Mavrilimumab (USAN/INN)
Other DBs
CAS: 1085337-57-0
PubChem: 124490622
LinkDB

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