KEGG   DRUG: UrelumabHelp
Entry
D09984                      Drug                                   

Name
Urelumab (USAN/INN)
Sequence
(Heavy chain) QVQLQQWGAG LLKPSETLSL TCAVYGGSFS GYYWSWIRQS
PEKGLEWIGE INHGGYVTYN PSLESRVTIS VDTSKNQFSL KLSSVTAADT AVYYCARDYG
PGNYDWYFDL WGRGTLVTVS SASTKGPSVF PLAPCSRSTS ESTAALGCLV KDYFPEPVTV
SWNSGALTSG VHTFPAVLQS SGLYSLSSVV TVPSSSLGTK TYTCNVDHKP SNTKVDKRVE
SKYGPPCPPC PAPEFLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSQE DPEVQFNWYV
DGVEVHNAKT KPREEQFNST YRVVSVLTVL HQDWLNGKEY KCKVSNKGLP SSIEKTISKA
KGQPREPQVY TLPPSQEEMT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD
SDGSFFLYSR LTVDKSRWQE GNVFSCSVMH EALHNHYTQK SLSLSLGK
(Disulfide bridge: 22-95; 148-204; 262-322; 368-426, Dimer: 227; 230)
(Light chain) EIVLTQSPAT LSLSPGERAT LSCRASQSVS SYLAWYQQKP
GQAPRLLIYD ASNRATGIPA RFSGSGSGTD FTLTISSLEP EDFAVYYCQQ RSNWPPALTF
CGGTKVEIKR TVAAPSVFIF PPSDEQLKSG TASVVCLLNN FYPREAKVQW KVDNALQSGN
SQESVTEQDS KDSTYSLSST LTLSKADYEK HKVYACEVTH QGLSSPVTKS FNRGEC
(Disulfide bridge: 23-88; 136-196; H135-L216, Dimer)
  Type
Peptide
Efficacy
Antineoplastic, Anti-CD137 antibody
Comment
Monoclonal antibody
Treatment of cancer, solid tumors
Target
TNFRSF9 (CD137) [HSA:3604] [KO:K05146]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Tumor necrosis factor receptors
    TNFRSF9 (CD137)
     D09984  Urelumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 934823-49-1
PubChem: 135626705
LinkDB All DBs

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