KEGG   DRUG: Ioflupane I 123
Entry
D10014                      Drug                                   
Name
Ioflupane I 123 (USAN);
Datscan (TN)
Product
DATSCAN (Medi-Physics Inc. dba GE Healthcare.)
  Generic
IOFLUPANE I 123 (Curium US LLC)
Formula
C18H23FINO2
Exact mass
427.0769
Mol weight
431.28
Structure
Simcomp
Remark
Therapeutic category: 4300
ATC code: V09AB03
Product: D10014<JP/US>
Efficacy
Diagnostic (SPECT imaging)
Comment
Diagnosis of Parkinson's disease (visualization for dopamine transporters: SLC6A3 (DAT1) [HSA:6531] [KO:K05036])
Target
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
  Pathway
hsa04728  Dopaminergic synapse
hsa05012  Parkinson disease
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V09 DIAGNOSTIC RADIOPHARMACEUTICALS
   V09A CENTRAL NERVOUS SYSTEM
    V09AB Iodine (123I) compounds
     V09AB03 Iodine ioflupane (123I)
      D10014  Ioflupane I 123 (USAN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  43  Radioactive drugs
   430  Radioactive drugs
    4300  Radioactive drugs
     D10014  Ioflupane I 123 (USAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A3 (DAT1)
     D10014  Ioflupane I 123 (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10014
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10014
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10014
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10014
Other DBs
CAS: 155798-07-5
PubChem: 135626735
ChEBI: 68855
LigandBox: D10014
LinkDB
KCF data

ATOM        23
            1   C1x C    20.4400  -20.9300
            2   C1x C    20.7900  -19.7400
            3   C1y C    21.6300  -20.6500
            4   C1y C    21.9800  -19.4600
            5   N1y N    20.7200  -18.1300
            6   C1x C    23.5200  -20.6500
            7   C1y C    23.2400  -19.4600
            8   C1y C    24.5700  -21.2100
            9   C8y C    25.6200  -22.0500
            10  C8x C    26.3200  -23.3100
            11  C8x C    27.7200  -23.3100
            12  C8y C    28.4200  -22.0500
            13  C8x C    27.7200  -20.8600
            14  C8x C    26.3200  -20.8600
            15  X   I    30.2400  -22.0500
            16  C7a C    23.8700  -18.2000
            17  O7a O    25.2700  -18.2000
            18  O6a O    23.1000  -17.0100
            19  C1a C    25.9700  -17.0100
            20  C1b C    19.5300  -17.4300
            21  C1b C    18.3400  -18.1300
            22  C1b C    17.1500  -17.4300
            23  X   F    15.9600  -18.1300
BOND        25
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     3   6 1
            6     4   7 1
            7     6   8 1
            8     8   9 1 #Up
            9     4   5 1
            10    7   8 1
            11    9  10 2
            12   10  11 1
            13   11  12 2
            14   12  13 1
            15   13  14 2
            16    9  14 1
            17   12  15 1
            18    7  16 1 #Up
            19   16  17 1
            20   16  18 2
            21   17  19 1
            22   20   5 1
            23   20  21 1
            24   21  22 1
            25   22  23 1

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