KEGG   DRUG: RobatumumabHelp
Entry
D10056                      Drug                                   

Name
Robatumumab (USAN/INN)
Formula
C6418H9960N1732O1992S42
Exact mass
144511.9584
Mol weight
144600.8942
Sequence
(Heavy chain) EVQLVQSGGG LVKPGGSLRL SCAASGFTFS SFAMHWVRQA
PGKGLEWISV IDTRGATYYA DSVKGRFTIS RDNAKNSLYL QMNSLRAEDT AVYYCARLGN
FYYGMDVWGQ GTTVTVSSAS TKGPSVFPLA PSSKSTSGGT AALGCLVKDY FPEPVTVSWN
SGALTSGVHT FPAVLQSSGL YSLSSVVTVP SSSLGTQTYI CNVNHKPSNT KVDKKVEPKS
CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV
DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA
KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD
SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGK
(Light chain) EIVLTQSPGT LSVSPGERAT LSCRASQSIG SSLHWYQQKP
GQAPRLLIKY ASQSLSGIPD RFSGSGSGTD FTLTISRLEP EDFAVYYCHQ SSRLPHTFGQ
GTKVEIKRTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ
ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(dimer; dislfide bridge: H22-H95, H145-H201, H221-L214, H227-H'227, H230-H'230, H262-H322, H368-H426, H'22-H'95, H'145-H'201, H'221-L'214, H'262-H'322, H'368-H'426, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Antineoplastic, Insulin-like growth factor 1 receptor antibody
Comment
Monoclonal antibody
Target
IGF1R (CD221) [HSA:3480] [KO:K05087]
  Pathway
hsa04510  Focal adhesion
hsa04520  Adherens junction
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   INSR family
    IGF1R (CD221)
     D10056  Robatumumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 934235-44-6
PubChem: 135626776
LinkDB All DBs

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