KEGG   DRUG: NarnatumabHelp
Entry
D10074                      Drug                                   

Name
Narnatumab (USAN)
Formula
C6454H10026N1754O2020S44
Exact mass
145830.3442
Mol weight
145920.064
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGFTFS SYLMTWVRQA PGKGLEWVAN IKQDGSEKYY
VDSVKGRFTI SRDNAKNSLN LQMNSLRAED TAVYYCTRDG YSSGRHYGMD VWGQGTTVIV
SSASTKGPSV FPLAPSSKST SGGTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ
SSGLYSLSSV VTVPSSSLGT QTYICNVNHK PSNTKVDKRV EPKSCDKTHT CPPCPAPELL
GGPSVFLFPP YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE
PQVYTLPPSR EEMTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF
LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK
(Light chain)
EIVLTQSPAT LSLSPGERAT LSCRASQSVS RYLAWYQQKP GQAPRLLIYDASNRATGIPA
RFSGSGSGTD FTLTISSLEP EDFAVYYCQQ RSNWPRTFGQGTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKVDNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQGLSSPVTKSFN RGEC
(dimer; disulfide bridge: H22-H96, H149-H205, H225-L214, H231-H'231, H234-H'234, H266-H326, H372-H430, H'22-H'96, H'149-H'205, H'225-L'214, H'266-H'326, H'372-H'430, L23-L88, L134-L194, L'23-L'88, L134-L'19)
  Type
Peptide
Efficacy
Antineoplastic
Comment
Monoclonal antibody
Target
RON [HSA:4486] [KO:K05100]
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   MET family
    RON
     D10074  Narnatumab (USAN)
BRITE hierarchy
Other DBs
PubChem: 135626794
LinkDB All DBs

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