KEGG   DRUG: CrenezumabHelp
Entry
D10101                      Drug                                   

Name
Crenezumab (USAN);
Crenezumab (genetical recombination) (JAN)
Formula
C6348H9796N1688O2010S44
Exact mass
143242.3924
Mol weight
143330.6674
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGFTFS SYGMSWVRQA PGKGLELVAS INSNGGSTYY
PDSVKGRFTI SRDNAKNSLY LQMNSLRAED TAVYYCASGD YWGQGTTVTV SSASTKGPSV
FPLAPCSRST SESTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ SSGLYSLSSV
VTVPSSSLGT KTYTCNVDHK PSNTKVDKRV ESKYGPPCPP CPAPEFLGGP SVFLFPPKPK
DTLMISRTPE VTCVVVDVSQ EDPEVQFNWY VDGVEVHNAK TKPREEQFNS TYRVVSVLTV
LHQDWLNGKE YKCKVSNKGL PSSIEKTISK AKGQPREPQV YTLPPSQEEM TKNQVSLTCL
VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS RLTVDKSRWQ EGNVFSCSVM
HEALHNHYTQ KSLSLSLG
(Light chain)
DIVMTQSPLS LPVTPGEPAS ISCRSSQSLV YSNGDTYLHW YLQKPGQSPQ LLIYKVSNRF
SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCSQSTHVP WTFGQGTKVE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(dimer; disulfide bridge: H22-H96, H126-L219, H139-H195, H218-H'218, H221-H'221, H253-H313, H359-H417, H'22-H'96, H'126-L'219, H'139-H'195, H'253-H'313, H'359-H'417, L23-L93, L139-L199, L'23-L'199)
  Type
Peptide
Class
Neuropsychiatric agent
 DG01968  Agents for Alzheimer-type dementia
Efficacy
Dementia therapeutic agent
Comment
Monoclonal antibody
Treatment of Alzheimer's disease
Target
beta-amyloid
Interaction
Drug interaction
Other DBs
CAS: 1095207-05-8
PubChem: 135626819
LinkDB All DBs

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