KEGG   DRUG: Pateclizumab
Entry
D10187                      Drug                                   
Name
Pateclizumab (USAN)
Formula
C6436H9910N1710O2004S44
Exact mass
144625.3826
Mol weight
144714.6652
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGYTFT SYVIHWVRQA PGKGLEWVGY NNPYNAGTNY
NEKFKGRFTI SSDKSKNTAY LQMNSLRAED TAVYYCSRPT MLPWFAYWGQ GTLVTVSSAS
TKGPSVFPLA PSSKSTSGGT AALGCLVKDY FPEPVTVSWN SGALTSGVHT FPAVLQSSGL
YSLSSVVTVP SSSLGTQTYI CNVNHKPSNT KVDKKVEPKS CDKTHTCPPC PAPELLGGPS
VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST
YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSREEMT
KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ
GNVFSCSVMH EALHNHYTQK SLSLSPG
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASQAVS SAVAWYQQKP GKAPKLLIYS ASHRYTGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQE SYSTPWTFGQ GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H145-H201, H221-L214, H227-H'227, H230-H'230, H262-H322, H368-H426, H'22-H'96, H'145-H'201, H'221-L'214, H'262-H'322, H'368-H'426, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Class
Anti-inflammatory
 DG01985  Disease modifying anti-rheumatic drug (DMARD)
  DG01936  TNF inhibitor
Efficacy
Immunosuppressant, Anti-lymphotoxin alpha antibody
Comment
Monoclonal antibody
Immune diseases and disorders
Target
LTA (TNFB, TNFSF1) [HSA:4049] [KO:K05468]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
Interaction
Brite
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01985  Disease modifying anti-rheumatic drug (DMARD)
   DG01936  TNF inhibitor
    D10187  Pateclizumab
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    LTA (TNFB, TNFSF1)
     D10187  Pateclizumab (USAN)
Other DBs
CAS: 1202526-59-7
PubChem: 135626905
LinkDB

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