KEGG   DRUG: Linagliptin and metformin hydrochloride
Entry
D10264            Mixture   Drug                                   
Name
Linagliptin and metformin hydrochloride;
Jentaduet (TN)
Product
JENTADUETO (Boehringer Ingelheim Pharmaceuticals), JENTADUETO XR (Boehringer Ingelheim Pharmaceuticals)
Component
Linagliptin [DR:D09566], Metformin hydrochloride [DR:D00944]
Class
Antidiabetic agent
 DG02044  Hypoglycemic agent
  DG03032  Combination of metformin and DPP-4 inhibitor
Transporter substrate
 DG01665  ABCB1 substrate
Remark
ATC code: A10BD11
Product: D10264<US>
Efficacy
Antidiabetic
  Disease
Type 2 diabetes mellitus [DS:H00409]
Comment
Linagliptin is a P-glycoprotein (P-gp) substrate.
Metabolism
Transporter: ABCB1 [HSA:5243]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BD Combinations of oral blood glucose lowering drugs
     A10BD11 Metformin and linagliptin
      D10264  Linagliptin and metformin hydrochloride <US>
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Combinations
   Linagliptin/ Metformin Hydrochloride
    D10264  Linagliptin and metformin hydrochloride
Drug groups [BR:br08330]
 Antidiabetic agent
  DG02044  Hypoglycemic agent
   DG03032  Combination of metformin and DPP-4 inhibitor
    D10264  Linagliptin and metformin hydrochloride
 Transporter substrate
  DG01665  ABCB1 substrate
   D10264  Linagliptin and metformin hydrochloride
Drug classes [BR:br08332]
 Antidiabetic agent
  DG02044  Hypoglycemic agent
   D10264  Linagliptin and metformin hydrochloride
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10264
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D10264
Other DBs
PubChem: 163312295
LinkDB

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