KEGG   DRUG: Balugrastim
Entry
D10310                      Drug                                   

Name
Balugrastim (USAN/INN)
Formula
C3776H5918N1008O1130S49
Exact mass
85032.2921
Mol weight
85086.6527
Sequence
DAHKSEVAHR FKDLGEENFK ALVLIAFAQY LQQCPFEDHV KLVNEVTEFA KTCVADESAE
NCDKSLHTLF GDKLCTVATL RETYGEMADC CAKQEPERNE CFLQHKDDNP NLPRLVRPEV
DVMCTAFHDN EETFLKKYLY EIARRHPYFY APELLFFAKR YKAAFTECCQ AADKAACLLP
KLDELRDEGK ASSAKQRLKC ASLQKFGERA FKAWAVARLS QRFPKAEFAE VSKLVTDLTK
VHTECCHGDL LECADDRADL AKYICENQDS ISSKLKECCE KPLLEKSHCI AEVENDEMPA
DLPSLAADFV ESKDVCKNYA EAKDVFLGMF LYEYARRHPD YSVVLLLRLA KTYETTLEKC
CAAADPHECY AKVFDEFKPL VEEPQNLIKQ NCELFEQLGE YKFQNALLVR YTKKVPQVST
PTLVEVSRNL GKVGSKCCKH PEAKRMPCAE DYLSVVLNQL CVLHEKTPVS DRVTKCCTES
LVNRRPCFSA LEVDETYVPK EFNAETFTFH ADICTLSEKE RQIKKQTALV ELVKHKPKAT
KEQLKAVMDD FAAFVEKCCK ADDKETCFAE EGKKLVAASQ AALGLTPLGP ASSLPQSFLL
KCLEQVRKIQ GDGAALQEKL CATYKLCHPE ELVLLGHSLG IPWAPLSSCP SQALQLAGCL
SQLHSGLFLY QGLLQALEGI SPELGPTLDT LQLDVADFAT TIWQQMEELG MAPALQPTQG
AMPAFASAFQ RRAGGVLVAS HLQSFLEVSY RVLRHLAQP
(Disulfide bridge: 53-62, 75-91, 90-101, 124-169, 168-177, 200-246, 245-253, 265-279, 278-289, 316-361, 360-369, 392-438, 437-448, 461-477, 476-487, 514-559, 558-567, 621-627 649-659)
  Type
Peptide
Class
Cardiovascular agent
 DG01753  Colony stimulating factor
  DG01781  Granulocyte colony stimulating factor (G-CSF)
Remark
ATC code: L03AA15
Efficacy
Antineutropenic, Granulocyte colony stimulating factor (G-CSF)
Comment
Treatment of chemotherapy-associated neutropenia
Target
CSF3R (GCSFR, CD114) [HSA:1441] [KO:K05061]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04640  Hematopoietic cell lineage
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L03 IMMUNOSTIMULANTS
   L03A IMMUNOSTIMULANTS
    L03AA Colony stimulating factors
     L03AA15 Balugrastim
      D10310  Balugrastim (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   CSF and other factor receptors
    CSF3R (GCSFR, CD114)
     D10310  Balugrastim (USAN/INN)
Other DBs
CAS: 527698-09-5
PubChem: 163312340
LinkDB

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