KEGG   DRUG: OzanezumabHelp
Entry
D10331                      Drug                                   

Name
Ozanezumab (USAN)
Formula
C6446H10016N1712O2010S48
Exact mass
145104.076
Mol weight
145193.8836
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKV SCKASGYTFT SYWMHWVRQA PGQGLEWIGN INPSNGGTNY
NEKFKSKATM TRDTSTSTAY MELSSLRSED TAVYYCELMQ GYWGQGTLVT VSSASTKGPS
VFPLAPSSKS TSGGTAALGC LVKDYFPEPV TVSWNSGALT SGVHTFPAVL QSSGLYSLSS
VVTVPSSSLG TQTYICNVNH KPSNTKVDKK VEPKSCDKTH TCPPCPAPEL AGAPSVFLFP
PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS
VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS RDELTKNQVS
LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS
CSVMHEALHN HYTQKSLSLS PGK
(Light chain)
DIVMTQSPLS NPVTLGQPVS ISCRSSKSLL YKDGKTYLNW FLQRPGQSPQ LLIYLMSTRA
SGVPDRFSGG GSGTDFTLKI SRVEAEDVGV YYCQQLVEYP LTFGQGTKLE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(dimer; disulfide bridges: H22-H96, H140-H196, H216-L219, H222-H'222, H225-H'225, H257-H317, H363-H421, H'22-H'96, H'140-H'196, H'216-L'219, H'257-H'-317, H'363-H'421, L23-L93, L139-L199, L'23-L'93, L'139-L'199)
  Type
Peptide
Efficacy
Nogo protein inhibitor
Comment
Monoclonal antibody
Treatment of ALS and multiple sclerosis
Target
RTN4 [HSA:57142] [KO:K20720]
Brite
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Cellular components
   Chromosome
    RTN4
     D10331  Ozanezumab (USAN)
BRITE hierarchy
Other DBs
CAS: 1310680-64-8
PubChem: 172232425
LinkDB All DBs

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